Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

Søberg S, Löfgren J, Philipsen FE, Jensen M, Hansen AE, Ahrens E, Nystrup KB, Nielsen RD, Lundell C, Christensen RH (2021) Cell Reports Medicine

Key Takeaway

Regular winter swimmers (averaging 11 minutes/week of cold exposure) showed enhanced brown fat activity and improved metabolic markers compared to controls.

Summary

This landmark study compared healthy young men who regularly practiced winter swimming with non-swimming controls to examine metabolic adaptations to chronic cold exposure.

Winter swimmers averaged about 11 minutes per week of cold water exposure. The study found they had significantly enhanced brown adipose tissue (BAT) activity and improved cold-induced thermogenesis. This translated to better insulin sensitivity and lipid profiles.

The findings provide strong evidence that regular cold exposure, even in modest amounts, can produce meaningful metabolic benefits through brown fat activation.

Methods

  • Compared 8 habitual winter swimmers with 8 matched controls
  • PET-CT scans to measure brown adipose tissue activity
  • Cold exposure challenge (2 hours at 18°C air) to measure thermogenic response
  • Blood markers for metabolic health assessed

Key Results

  • Winter swimmers had higher BAT activity (+45% glucose uptake)
  • Enhanced cold-induced thermogenesis
  • Better insulin sensitivity in cold-exposed group
  • Average cold exposure was only 11 minutes per week

Limitations

  • Small sample size (n=16 total)
  • Cross-sectional design (cannot prove causation)
  • Only young men studied
  • Lifestyle differences between groups may confound results

Related Interventions

Source

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DOI: 10.1016/j.xcrm.2021.100408