Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Wilkinson MJ, Manoogian ENC, Zadourian A, Lo H, Fakhouri S, Shoghi A, Wang X, Fleischer JG, Navlakha S, Panda S, Taub PR (2020) Cell Metabolism

Key Takeaway

A 10-hour eating window improved multiple metabolic markers in people with metabolic syndrome, including weight, blood pressure, and cholesterol.

Summary

This human study examined time-restricted eating in patients with metabolic syndrome. Participants confined their eating to a self-selected 10-hour window for 12 weeks while using the myCircadianClock app to track their intake.

Results showed significant improvements across multiple health markers: 3% body weight reduction, lower blood pressure, reduced LDL cholesterol, and decreased HbA1c. Participants also reported better sleep and more energy.

Notably, participants were not told to change what they ate - only when. The study demonstrates real-world feasibility and benefits of TRE.

Methods

  • 19 adults with metabolic syndrome
  • 10-hour self-selected eating window
  • 12-week intervention
  • Tracked via myCircadianClock app

Key Results

  • 3% body weight reduction
  • Systolic blood pressure: -4 mmHg
  • LDL cholesterol: -11%
  • Improved sleep quality
  • 70% reduction in medications (some participants)

Limitations

  • Small sample size
  • No control group
  • Self-selected motivated participants
  • Metabolic syndrome population specifically

Related Interventions

Source

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DOI: 10.1016/j.cmet.2019.11.004