Coffee Enemas Research
1 peer-reviewed study supporting this intervention. Evidence rating: C
1
Studies
0
RCTs
0
Meta-analyses
2013
Year Range
Study Comparison
| Study | Year | Type | Journal | Key Finding |
|---|---|---|---|---|
| Teekachunhatean S et al. | 2013 | Study | ISRN Pharmacology | Coffee enema administration results in measurable plasma caffeine levels comparable to oral coffee, but via systemic rather than portal circulation - contradicting claims about direct liver effects. |
Study Details
ISRN Pharmacology
Key Finding: Coffee enema administration results in measurable plasma caffeine levels comparable to oral coffee, but via systemic rather than portal circulation - contradicting claims about direct liver effects.
View Summary
This pharmacokinetic study compared caffeine absorption from coffee administered rectally (enema) versus orally to examine whether coffee enemas actually reach the liver via the portal vein as proponents claim.
Results showed that rectal administration produced plasma caffeine levels, but the absorption pattern suggests systemic rather than portal circulation, challenging the theoretical basis for liver detoxification claims.
Evidence Assessment
This intervention has preliminary evidence from early-stage research, mechanistic studies, or observational data. More rigorous trials are needed.