The Skin Real ®

PRP vs. PRF: Which One Is Better?

The Skin Real ® with Dr. Mary Alice Mina 2025-04-03

Summary

Board-certified dermatologist Dr. Mary Alice Mina recaps her interview with Dr. Amelia Hausauer by busting five common PRP myths. She explains that PRP is backed by robust evidence for hair regrowth and also shows promise for acne scarring, skin rejuvenation, and accelerating healing after laser or microneedling treatments. The episode breaks down the difference between PRP and PRF (platelet-rich fibrin), concluding that PRF looks most promising for wound healing but is not yet ready for cosmetic use due to higher complication rates. Dr. Mina recommends starting PRP for hair loss within the first five years of noticing thinning, avoiding NSAIDs before treatment, staying hydrated, and scheduling morning appointments when platelet counts tend to be higher.

Key Points

  • PRP is not a fad - it has robust evidence especially for hair regrowth
  • PRP varies between individuals and even between treatments due to differences in sleep, hydration, medications, and age
  • PRP is not a one-and-done treatment - hair loss typically requires monthly sessions then maintenance every 6-12 months
  • Results are not instant - signaling molecules stimulate collagen and healing over weeks to months
  • PRP is generally safe since it uses your own blood, but proper handling of blood products is critical
  • Start PRP for hair loss within the first 5 years of noticing thinning for best results
  • Avoid NSAIDs for about a week before treatment and stay well hydrated
  • PRF (platelet-rich fibrin) looks promising for wound healing but has more complications for cosmetic use - stick with PRP for now

Key Moments

PRP is a form of regenerative medicine with real science behind it

Dr. Mina explains that PRP is a type of regenerative medicine that concentrates platelets with growth factors, exosomes, and cytokines. It has the strongest evidence for hair regrowth but also helps with acne scarring and skin regeneration after laser treatments.

"PRP, it is not hype. It really does work. And it's a very cool component of regenerative medicine."

PRP varies between people based on sleep, hydration, medications, and age

Unlike standardized medications like Botox, PRP comes from your own blood and varies based on individual factors. Even your own PRP will differ between treatments depending on sleep, hydration, medications, and age.

"PRP comes from our own blood and every single person out there is different and unique. And guess what? Every single day, your blood will have different concentrations of platelets, depending on if you got a lot of sleep, if you're dehydrated, what medications you're on, your age."

PRF is not yet ready for cosmetic procedures - stick with PRP

PRF (platelet-rich fibrin) is a clot-like substance that may help with wound healing but has more complications when used for cosmetic procedures. Dr. Mina recommends sticking with proven PRP until better PRF data emerges.

"PRF looks the most promising for wound healing and not yet ready for prime time with cosmetic procedures, at least the data that we have."

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