Key Takeaway
2.5g collagen peptides daily reduced eye wrinkle volume by 20% and increased procollagen I production by 65% after 8 weeks compared to placebo.
Summary
This double-blind, placebo-controlled trial tested whether specific bioactive collagen peptides (VERISOL) could reduce wrinkles and stimulate skin matrix production. 114 women aged 45-65 received either 2.5g collagen peptides or placebo daily for 8 weeks.
The collagen group showed significant reductions in eye wrinkle volume and increased production of key skin matrix proteins. Benefits persisted 4 weeks after stopping supplementation, suggesting lasting effects on skin structure.
Methods
- 114 women aged 45-65 years
- 8-week randomized double-blind placebo-controlled trial
- Treatment: 2.5g bioactive collagen peptides (VERISOL) daily
- Measured: eye wrinkle volume (skin surface profilometry)
- Subset (n=22): skin biopsies for procollagen I, elastin, fibrillin
Key Results
After 8 weeks (collagen vs placebo):
- Eye wrinkle volume: 20% reduction (p < 0.05)
- Procollagen type I: 65% higher content
- Elastin: 18% higher content
- Fibrillin: 6% higher (not statistically significant)
- Benefits persisted 4 weeks after last dose
Limitations
- Only women studied (45-65 years)
- Funded by GELITA AG (collagen manufacturer)
- Small biopsy subset (n=22)
- Eye wrinkles only (may not generalize to other areas)