Key Takeaway
A comprehensive review across medical and surgical specialties finds PRP shows promise in orthopedics, dermatology, and wound healing, but highlights significant variability in preparation protocols as a barrier to standardized clinical use.
Summary
This systematic review evaluated platelet-rich plasma (PRP) applications across a wide range of medical and surgical specialties, assessing the quality of evidence, preparation methods, and clinical outcomes.
The authors found that PRP demonstrates meaningful clinical benefits in several areas, particularly orthopedic conditions (osteoarthritis, tendinopathies), dermatological applications (hair restoration, skin rejuvenation), and chronic wound management. However, the review identified significant heterogeneity in PRP preparation protocols across studies.
The authors emphasize that the lack of standardized PRP preparation and classification systems remains the primary obstacle to establishing definitive clinical guidelines, and call for regulatory enforcement of preparation standards to improve reproducibility and evidence quality across specialties.
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