Key Takeaway
Meta-analysis found collagen supplementation may improve knee osteoarthritis symptoms, though evidence quality varies and more rigorous trials are needed
Summary
This systematic review and meta-analysis assessed the clinical efficacy of collagen-based supplements on knee osteoarthritis symptoms. Searches conducted until October 2023 across MEDLINE, EMBASE, Web of Science, and Scopus identified RCTs evaluating oral collagen supplements for knee OA.
Methods
Systematic review and meta-analysis searching MEDLINE, EMBASE, Web of Science, and Scopus through October 2023. Included RCTs of oral collagen-based supplements for knee OA. Assessed pain, function, and stiffness outcomes.
Key Results
Collagen supplementation showed potential benefits for knee OA symptoms including pain reduction and functional improvement. Effect sizes varied by collagen type and dosing protocol.
Limitations
Heterogeneous collagen types (hydrolyzed, undenatured, type I, type II). Variable dosing protocols. Industry funding in many trials. Limited long-term follow-up. Some studies at high risk of bias.