The effect of nicotine on sustained attention in nonsmokers

Valentine G, Sofuoglu M (1997) Psychopharmacology

Key Takeaway

Nicotine significantly improved sustained attention in non-smokers, demonstrating cognitive enhancement effects independent of addiction or withdrawal.

Summary

This study specifically examined nicotine's effects on sustained attention in non-smokers, eliminating the confound of withdrawal reversal. Participants received nicotine via nasal spray and performed attention tasks.

Results showed significant improvements in sustained attention, particularly on tasks requiring prolonged vigilance. These findings confirm that nicotine's attention-enhancing effects are genuine cognitive enhancement rather than simply normalizing smoker performance.

The study supports nicotine as a legitimate nootropic for attention in nicotine-naive individuals.

Methods

  • Double-blind, placebo-controlled
  • Non-smoker participants
  • Nicotine nasal spray delivery
  • Sustained attention tasks

Key Results

  • Improved sustained attention
  • Enhanced vigilance on prolonged tasks
  • Effects in nicotine-naive subjects
  • Dose-dependent improvements

Limitations

  • Acute effects only
  • Nasal spray delivery may differ from other methods
  • Small sample size
  • Single cognitive domain tested

Related Interventions

Source

View on PubMed →

DOI: 10.1007/s002130050392