Nicotine

Mechanisms:

• Binds to nicotinic acetylcholine receptors (nAChRs) in the brain
• Increases release of dopamine, norepinephrine, and acetylcholine
• Enhances attention, working memory, and processing speed
• Effects are acute (within minutes) and last 1-2 hours
• Upregulates nicotinic receptors with repeated use (tolerance/dependence pathway)

Key concepts:

• Nicotine ≠ tobacco - most harms of smoking come from combustion, not nicotine itself
• Dose-response curve is steep - more is not better, often worse
• Naive users (non-smokers) are more sensitive and need lower doses
• Half-life is ~2 hours, but metabolite cotinine lasts longer
• Receptor upregulation with daily use creates physical dependence

Evidence base:

• Consistent improvements in attention and reaction time across studies
• Memory enhancement documented, especially in attention-demanding tasks
• Most research conducted on smokers or for smoking cessation
• Limited direct research on low-dose cognitive enhancement in non-smokers
• Dave Asprey and other biohackers have popularized intermittent protocols

Limitations:

• Addiction potential is real - daily use leads to dependence
• Most studies not designed for the nootropic use case
• Individual response varies significantly
• Long-term effects of intermittent low-dose use not well-studied
• Cardiovascular effects (vasoconstriction, heart rate increase) may concern some users

Getting started:

1. Start very low - 1mg or less for nicotine-naive users (cut gum/pouches if needed)
2. Test your response - First time, use in a safe setting to assess tolerance
3. Set hard limits upfront - Max 2-3 uses per week, never consecutive days
4. Track your use - Easy to slip into more frequent use without noticing
5. Take regular breaks - At least one week off per month

Dosing guidelines:

• Nicotine-naive: Start with 0.5-1mg, max 2mg per use
• Former smokers: 2-4mg may be appropriate, but higher addiction risk
• Timing: Effects peak in 15-30 minutes, last 1-2 hours
• Use case: Best for focused work blocks, not all-day use

Frequency rules (critical):

• Maximum: 2-3 times per week
• Never: Daily use or consecutive days
• Pattern: Use only for specific high-value focus sessions
• Red line: If you feel you "need" it, stop immediately and take 2+ weeks off

Delivery method guidance:

• Gum (2mg): Chew briefly, then park between cheek and gum. Cut in half for 1mg.
• Pouches (various strengths): Sublingual absorption, 20-30 min use. Start with lowest strength (1-3mg).
• Patches (7mg, 14mg, 21mg): Cut for lower doses. Steadier release, less acute "hit."

Risks:

• Addiction/dependence with frequent use (primary concern)
• Nausea, dizziness, hiccups at higher doses
• Increased heart rate and blood pressure (vasoconstriction)
• Potential cardiovascular stress with pre-existing conditions
• Gateway to other nicotine products or tobacco
• Microplastics and artificial ingredients in some pouches/gums

Ingredient concerns:

• Some pouches contain microplastics from the pouch material
• Artificial sweeteners (sucralose, acesulfame-K) in most flavored products
• Look for cleaner brands or unflavored options if this concerns you
• Gum may contain more additives than pouches

Contraindications - do NOT use if:

• History of nicotine/tobacco addiction
• Cardiovascular disease, arrhythmias, or uncontrolled hypertension
• Pregnant or breastfeeding
• Under 25 (brain still developing)
• History of addiction to other substances
• Taking MAOIs or certain psychiatric medications

Warning signs to stop:

• Using more frequently than planned
• Thinking about nicotine between uses
• Feeling irritable or foggy on non-use days
• "Needing" it for baseline function
• Increasing dose for same effect

Key metrics:

• Usage frequency (stick to 2-3x/week max)
• Dose per use
• Subjective focus/productivity rating
• Any craving or dependency signs
• Side effects (nausea, heart rate, etc.)

Signs it's working:

• Enhanced focus during work sessions
• Improved attention on demanding tasks
• No increase in usage frequency over time
• No cravings or withdrawal between uses
• Clear "on/off" - returns to baseline cleanly

Nicotine pouches:

• Zyn - Most widely available, various strengths (3mg, 6mg)
• On! - Smaller pouches, lower strengths available (2mg)
• Lucy - Marketed to biohackers, cleaner branding
• Rogue - Tobacco-free pouches

Nicotine gum:

• Nicorette - Widely available, 2mg and 4mg options
• Lucy Gum - Cleaner positioning, biohacker-friendly
• Generic pharmacy brands - Often cheaper, same active ingredient

Patches:

• Nicoderm CQ, Habitrol, or generic - can cut to lower doses

Microplastic/ingredient note: Most pouches contain synthetic fibers. If concerned, nicotine gum may be preferable despite more additives. No perfect option exists - choose your tradeoff.

Key voices:

• Dave Asprey - Bulletproof founder, vocal advocate for low-dose nicotine as nootropic
• Andrew Huberman - Discusses nicotine pharmacology and acetylcholine system
• Ben Greenfield - Has discussed nicotine for cognitive enhancement

Online communities:

• r/Nootropics - Frequent nicotine discussions
• Biohacker forums and podcasts

Common positive reports:

• "Incredible focus for deep work sessions"
• "Better than caffeine for attention"
• "No jitters like stimulants"
• "Great for occasional high-stakes work"

Common complaints:

• "Easy to slip into daily use"
• "Nausea at first until I found right dose"
• "Worried about addiction"
• "Tolerance builds if overused"

Pairs well with:

• Caffeine - Classic stack; nicotine + caffeine is synergistic for alertness. Start with lower doses of each.
• Creatine - Both support cognitive function through different mechanisms
• Time-Restricted Eating - Some find nicotine blunts appetite; can support fasted focus work

Timing considerations:

• Morning or early afternoon use (avoid evening - can affect sleep)
• Pair with specific work blocks, not general use
• Don't combine with other stimulants initially

Stacks with:

• Cognitive enhancement protocols
• Deep work / focus systems
• Intermittent fasting (appetite suppression)