Summary
Andrew Huberman covers the neuroscience of nicotine, including its effects on acetylcholine receptors, dopamine release, and cognitive enhancement, while addressing addiction risks and harm reduction.
Key Points
- Nicotine binds to nicotinic acetylcholine receptors
- Increases dopamine, norepinephrine, and acetylcholine
- Genuine cognitive enhancement in attention and memory
- Effects peak in 15-30 minutes, last 1-2 hours
- Addiction risk is real with frequent use
- Delivery method matters - avoid smoking and vaping
- Patches and gum can be cut for lower doses
- Not recommended for those under 25