The Human Upgrade

How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350

The Human Upgrade with Dave Asprey 2025-10-23

Summary

The Human Upgrade episode covering biohacking strategies for peak performance and longevity.

Key Points

  • Biohacking for optimization
  • Technology and biology combined
  • Practical implementation

Key Moments

Nicotine

Nicotine masterclass part 2: the inverted U-curve and addiction threshold above 10mg/day

Asprey recaps that nicotine is not the same as smoking, follows an inverted U-curve for benefits, and carries real addiction risk above 10mg per day. Higher blood pressure, poor sleep, and insulin sensitivity changes are documented risks.

"Higher blood pressure, bad sleep, insulin sensitivity, and why context matters. Nicotine is a powerful."
Nicotine

Real-world nicotine templates: avoid artificial sweeteners, use 1-2mg doses strategically

WADA monitors nicotine because it works for performance. Asprey recommends avoiding products with artificial sweeteners and using small controlled doses. He provides practical templates for jet lag, focus, and daily cognitive enhancement.

"First of all, many nicotine products contain artificial sweeteners or microplastics, especially artificial sweeteners. I am not a fan of those."

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