The Cabral Concept

Why Methylation Supplements Usually Backfire

The Cabral Concept with Stephen Cabral 2026-01-15

Summary

Dr. Cabral discusses why simply taking methylated B vitamins without proper testing and context often causes more harm than good. He explains the methylation cycle, MTHFR variations, and a more balanced approach to supporting methylation.

Key Points

  • Why methylated supplements can backfire
  • Understanding the methylation cycle
  • MTHFR gene variations and what they mean
  • The importance of testing before supplementing
  • Balancing methylation support
  • Signs of over-methylation

Key Moments

B12 and B9 are cargo; B2 is the engine

Methylated B12 and B9 alone won't fix methylation. Riboflavin (B2) converts to FAD, which actually shuttles methyl groups.

"If B9 and B12 are the cargo, B2 is the engine. Riboflavin is converted to FAD, an electron carrier that shuttles things from one place to another."

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