Huberman Lab

Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo

Huberman Lab with Andrew Huberman 2025-05-26

Summary

Episode exploring how behaviors can alter gene expression through epigenetic mechanisms, with practical interventions for optimizing genetic health.

Key Points

  • Behaviors influence gene expression
  • Epigenetics bridges nature and nurture
  • Exercise affects gene methylation
  • Diet impacts epigenetic markers
  • Stress alters gene expression
  • Lifestyle interventions are powerful

Key Moments

Dive reflex and the spleen: how cold water face immersion deploys extra red blood cells

Sea-diving populations evolved larger spleens and higher red blood cell counts via thyroid hormone gene variants. The dive reflex (cold water on face + breath hold) triggers spleen contraction, releasing stored red blood cells.

"This is like an erythropoietin independent mechanism of increasing your red blood cell count that could have an advantage in performance."

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