Huberman Lab

Healing From Grief & Loss | Dr. Mary-Frances O'Connor

Huberman Lab with Dr. Mary-Frances O'Connor 2025-06-02

Summary

Dr. Mary-Frances O'Connor discusses the neuroscience of grief and loss, including how the brain processes attachment and practical approaches to healing.

Key Points

  • Grief is a learning process for the brain
  • Attachment bonds persist neurologically
  • Time and processing aid healing
  • Physical health impacts grief recovery
  • Social support is protective
  • Professional help when needed

Key Moments

Grief rewires the brain like addiction

Dr. O'Connor explains how grief shares neural circuitry with addiction - the brain's mapping of a loved one becomes disrupted, and the longing to be reunited activates the same reward pathways as substance cravings, explaining why grief can feel like withdrawal.

"I loosely define addiction as a progressive narrowing of the things that bring you pleasure."
Grief And Loss

Disordered grief affects one in ten and raises medical risk

O'Connor describes how about 10% of bereaved people develop disordered grieving where time passing doesn't help, and how grief significantly increases risk of heart attack, immune dysfunction, and other medical conditions for both the grieving person and those around them.

"We do know for the one out of ten who develop disordered grieving, who really are not showing any changes over time, even though time is passing, those people need help."

Break the rumination cycle by simply getting up and walking

O'Connor shares a practical tool for grief rumination - when you catch yourself in repetitive questioning loops, literally get up and walk outside. The physical shift alone changes thought patterns, and the key question is not whether a thought is true but whether it is helpful.

"If I realize, oh, I'm doing the rumination thing again, literally, I just need to get up and walk outside, right? Just that shift alone can help to change my thought patterns."

Progressive muscle relaxation beats mindfulness for grief

A study comparing mindfulness training to progressive muscle relaxation in widows and widowers found that while both helped, progressive muscle relaxation was even more effective for grief management.

"Turns out mindfulness training was helpful, but progressive muscle relaxation was even more helpful for people's grief."

Featured Experts