Raw Honey Research

8 peer-reviewed studies supporting this intervention. Evidence rating: B

8 Studies
1 RCTs
3 Meta-analyses
2008-2024 Year Range

Study Comparison

Study Year Type Journal Key Finding
Tang Y et al. 2024 Meta-analysis Nutrients Honey dressings significantly shorten wound healing time, increase complete healing rates, and reduce bacterial load in chronic wounds compared to conventional dressings.
Yildiz Karadeniz E et al. 2023 Meta-analysis Journal of tissue viability Honey-based wound care significantly improves healing rates and reduces wound size in diabetic foot ulcers compared to standard treatments.
Abuelgasim H et al. 2021 Meta-analysis BMJ evidence-based medicine Honey is superior to usual care for improving upper respiratory tract infection symptoms, particularly cough frequency and severity, and represents a widely available alternative to antibiotics.
Oduwole O et al. 2018 Study Cochrane Database of Systematic Reviews Cochrane review found honey probably reduces cough symptoms in children more effectively than placebo and diphenhydramine, and may be similar to dextromethorphan.
Samarghandian S et al. 2017 Study Pharmacognosy Research Comprehensive review found honey has antimicrobial, antioxidant, and wound-healing properties supported by clinical research.
Erejuwa OO et al. 2012 Study Molecules Despite being a sugar source, honey has paradoxical anti-diabetic effects including improved glycemic control and reduced oxidative stress in diabetic subjects.
Bogdanov S et al. 2009 Study Journal of the American College of Nutrition Authoritative review establishing honey's nutritional composition and evidence-based health benefits, including antimicrobial and antioxidant effects.
Paul IM et al. 2008 RCT Archives of Pediatrics & Adolescent Medicine A single dose of honey before bed was more effective than dextromethorphan (cough medicine) for reducing nighttime cough and improving sleep in children.

Study Details

Tang Y, Chen L, Ran X

Nutrients

Key Finding: Honey dressings significantly shorten wound healing time, increase complete healing rates, and reduce bacterial load in chronic wounds compared to conventional dressings.
View Summary

This updated systematic review and meta-analysis evaluated the efficacy and safety of honey dressings for managing chronic wounds. The authors searched PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials comparing honey dressings with conventional wound care.

The meta-analysis included multiple RCTs and found that honey dressings significantly reduced mean wound healing time, increased the rate of complete wound healing at various follow-up time points, and improved the percentage of wound area healed compared to control dressings. Honey-treated wounds also showed significantly greater bacterial clearance rates.

Sensitivity analyses confirmed the robustness of these findings, and funnel plots indicated no significant publication bias. The authors concluded that honey dressings are an effective and safe adjunctive therapy for chronic wound management, with benefits attributed to honey's antimicrobial, anti-inflammatory, and tissue-regenerating properties.

Yildiz Karadeniz E, Kaplan Serin E

Journal of tissue viability

Key Finding: Honey-based wound care significantly improves healing rates and reduces wound size in diabetic foot ulcers compared to standard treatments.
View Summary

This systematic review and meta-analysis assessed the effectiveness of honey in the treatment of diabetic foot ulcers (DFUs). The authors conducted a comprehensive literature search across major databases for randomized controlled trials comparing honey-based interventions to conventional wound care in patients with DFUs.

The pooled analysis found that honey treatment was associated with significantly higher rates of complete wound healing and greater reductions in wound surface area compared to standard dressings. Honey-treated ulcers also demonstrated faster healing trajectories, with shorter mean time to wound closure.

The authors noted that honey's broad-spectrum antimicrobial activity, ability to maintain a moist wound environment, and anti-inflammatory effects make it a particularly promising adjunct for diabetic wounds, which are notoriously difficult to heal due to impaired circulation and immune function. They concluded that honey is a safe and effective complementary therapy for diabetic foot ulcer management.

Abuelgasim H, Albury C, Lee J

BMJ evidence-based medicine

Key Finding: Honey is superior to usual care for improving upper respiratory tract infection symptoms, particularly cough frequency and severity, and represents a widely available alternative to antibiotics.
View Summary

This systematic review and meta-analysis, published in BMJ Evidence-Based Medicine, evaluated the effectiveness of honey for symptomatic relief in upper respiratory tract infections (URTIs). The authors searched six databases for studies comparing honey to usual care, placebo, or no treatment for URTI symptoms.

The pooled analysis of 14 studies found that honey was significantly superior to usual care for improving composite symptom scores, cough frequency, and cough severity. The effects were consistent across multiple study designs and populations, including both adults and children.

The findings are particularly relevant given the global push to reduce inappropriate antibiotic prescribing for URTIs. The authors highlighted that honey is a widely available, low-cost remedy with a favorable safety profile, making it a viable first-line treatment for URTI symptoms. They recommended honey as an alternative to antibiotics when clinicians wish to offer a safe treatment for upper respiratory symptoms.

Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM

Cochrane Database of Systematic Reviews

Key Finding: Cochrane review found honey probably reduces cough symptoms in children more effectively than placebo and diphenhydramine, and may be similar to dextromethorphan.
View Summary

Definitive Cochrane review on honey for pediatric cough.

Samarghandian S, Farkhondeh T, Samini F

Pharmacognosy Research

Key Finding: Comprehensive review found honey has antimicrobial, antioxidant, and wound-healing properties supported by clinical research.
View Summary

Review of clinical evidence for honey's health benefits.

Erejuwa OO, Sulaiman SA, Wahab MSA

Molecules

Key Finding: Despite being a sugar source, honey has paradoxical anti-diabetic effects including improved glycemic control and reduced oxidative stress in diabetic subjects.
View Summary

This review examines the seemingly paradoxical beneficial effects of honey on metabolic health and diabetes markers.

Evidence suggests honey may improve glycemic control, reduce oxidative stress, and have protective effects on pancreatic beta cells compared to refined sugars.

Bogdanov S, Jurendic T, Sieber R, Gallmann P

Journal of the American College of Nutrition

Key Finding: Authoritative review establishing honey's nutritional composition and evidence-based health benefits, including antimicrobial and antioxidant effects.
View Summary

Comprehensive scientific review of honey's composition and health effects.

Paul IM, Beiler J, McMonagle A, et al

Archives of Pediatrics & Adolescent Medicine

Key Finding: A single dose of honey before bed was more effective than dextromethorphan (cough medicine) for reducing nighttime cough and improving sleep in children.
View Summary

This randomized controlled trial compared honey to a common cough suppressant for childhood cough.

Children receiving buckwheat honey before bed had greater reductions in cough frequency and severity, and better sleep quality, than those receiving dextromethorphan or no treatment.

Evidence Assessment

B Moderate Evidence

This intervention has moderate evidence from some randomized trials and consistent observational data, though more research would strengthen conclusions.