Key Takeaway
Bovine colostrum prevented the increase in gut permeability caused by NSAIDs in healthy volunteers, suggesting protective effects on the intestinal lining.
Summary
Study examining whether bovine colostrum could protect against NSAID-induced intestinal damage in healthy humans.
Methods
- Randomized, double-blind crossover
- 7 healthy volunteers
- Co-administration of colostrum with indomethacin
- Measured gut permeability via lactulose/mannitol test
Key Results
- Colostrum prevented NSAID-induced permeability increase
- 3-fold rise in permeability with NSAID alone
- No rise when colostrum co-administered
- Suggests mucosal protective effect
Figures
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Limitations
- Very small sample size
- Acute study design
- Healthy volunteers only
- Single NSAID tested