Key Takeaway
Bovine colostrum reduced NSAID-induced gut permeability by 80% in healthy volunteers, confirming its protective effects on intestinal barrier function.
Summary
Follow-up study confirming that bovine colostrum protects against NSAID-induced intestinal damage in a larger group of healthy volunteers.
Methods
- Randomized, double-blind, placebo-controlled
- 15 healthy volunteers
- Indomethacin challenge with/without colostrum
- Intestinal permeability measured by sugar absorption test
Key Results
- NSAID increased gut permeability 3.5-fold
- Colostrum co-administration reduced this by 80%
- Dose-dependent protective effect
- Growth factors in colostrum likely mechanism
Limitations
- Short-term acute study
- Healthy volunteers only
- Single NSAID tested
- Mechanism not fully elucidated