Summary
Dr. Steven Gundry joins Dr. Jockers to discuss the relationship between intestinal permeability, mitochondrial dysfunction, and the ketogenic approach outlined in his book 'Unlocking the Keto Code.' They explore how specific polyphenols and postbiotics can repair gut barriers and restore mitochondrial function.
Key Points
- Mitochondrial uncoupling is a key mechanism behind ketogenic diet benefits
- Polyphenols and postbiotics support mitochondrial health independent of ketosis
- Lectins and other plant compounds can trigger leaky gut in susceptible individuals
- Short-chain fatty acids from fiber fermentation support gut barrier integrity
- Time-restricted eating enhances the benefits of a ketogenic approach
Key Moments
Ketogenic Diet: But even at full ketosis
But even at full ketosis, the brain still will use 30 to 40 percent of its energy as glucose. And so the idea that ketones were some miraculous fuel was actually not there in experiments on humans.
"But even at full ketosis, the brain still will use 30 to 40 percent of its energy as glucose. And so the idea that ketones were some miraculous fuel was actually not there in experiments on humans. So when I was trying to explain in my last book, The Energy Paradox, the benefit of ketones, I kept running into this wall going, well, wait a minute, they're not a super fuel."
And so, yeah, and it was the same calories, the same exercise program
Only the athletes who had a reduced eating window dramatically lowered their insulin-like growth factor one, IGF-1, which I think is still for most of us, the best measurement we have of aging that is readily accessible. And so, yeah, and it was the same calories, the same exercise program.
"Only the athletes who had a reduced eating window dramatically lowered their insulin-like growth factor one, IGF-1, which I think is still for most of us, the best measurement we have of aging that is readily accessible. And so, yeah, and it was the same calories, the same exercise program. And you're right."
Ketogenic Diet: And if you think about it as a plant defense
And if you think about it as a plant defense mechanism, if you produce leaks in the wall of the gut and 70 to 80 percent of your immune system, white blood cells are lining the wall of the gut, and they see foreign particles coming across the gut, as well as bacterial particles, you can produce some
"And if you think about it as a plant defense mechanism, if you produce leaks in the wall of the gut and 70 to 80 percent of your immune system, white blood cells are lining the wall of the gut, and they see foreign particles coming across the gut, as well as bacterial particles, you can produce some pretty impressive inflammation."
We just shotgun everybody and it was miraculous
I was actually a medical student when broad-spectrum antibiotics came out in the 70s. And we just thought it was miraculous that we could give somebody a pill without worrying about having to identify which bacteria was causing this.
"I was actually a medical student when broad-spectrum antibiotics came out in the 70s. And we just thought it was miraculous that we could give somebody a pill without worrying about having to identify which bacteria was causing this. We just shotgun everybody and it was miraculous. Little did we know that we were also miraculously killing off our tropical rainforest that lived in our gut, our gut microbiome."
