Huberman Lab

How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

Huberman Lab with Keith Humphreys 2026-01-12

Summary

40-60% of addiction risk is genetic, but recovery approaches work regardless of predisposition. 12-step programs remain highly effective as free, accessible community support with strong long-term outcomes. Emerging treatments like TMS, SAINT protocol, and ibogaine show promise when integrated into clinical care.

Key Points

  • Approximately 40-60% of addiction risk is heritable, making some individuals more vulnerable to developing dependencies than others
  • Alcohol carries substantial health risks beyond addiction, including increased cancer risk, with social pressure often driving problematic use
  • Modern cannabis products pose greater risks due to dramatically increased THC concentrations and potential links to psychosis in developing brains
  • 12-step programs like AA remain highly effective, offering accessible, low-cost community support with strong evidence for long-term recovery
  • Emerging neuromodulation therapies show promise, including transcranial magnetic stimulation (TMS) and Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT)
  • Gambling machines and social media employ sophisticated behavioral techniques specifically engineered to maximize engagement and dependence
  • Psychedelics and ibogaine show potential for addiction treatment when integrated into clinical protocols

Key Moments

TMS can treat addiction by targeting brain areas

Transcranial magnetic stimulation non-invasively modulates brain activity in addiction, with strong double-blind evidence.

"But, you know, yeah, it's covered. I think Medicare actually covers it. Whether they cover the specific protocol that Nolan did, I'm honestly not sure, you know, because there was a lower intensity one. And New Orleans, you know, genius was to compress this treatment. So people would come in five days in a row and have 10 minutes on, 50 minutes off, I believe that's the thing, the rate, all day long, five days, and with a theta burst setting for the RTMS. And I've seen some people's lives just absolutely changed by that. And you can see as trial, I mean, it's a trial, it's a good trial, unlike what's like."

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