The Human Upgrade

The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404

The Human Upgrade with Dave Asprey 2026-01-25

Summary

Dave Asprey joins The Human Upgrade to discuss the natural ozempic in your gut (eat this to switch it on) : 1404. Key topics include performance optimization strategies backed by science; practical biohacking tools and technologies for health optimization; key longevity markers and interventions to optimize healthspan.

Key Points

  • Performance optimization strategies backed by science
  • Practical biohacking tools and technologies for health optimization
  • Key longevity markers and interventions to optimize healthspan

Key Moments

And if 12 to 14 hours seems like a lot, you probably slept for 8 hours

That means you can create a 12 to 14 hour overnight fasting window, so your gut lining can repair itself and inflammatory signals can calm down. And if 12 to 14 hours seems like a lot, you probably slept for 8 hours.

"That means you can create a 12 to 14 hour overnight fasting window, so your gut lining can repair itself and inflammatory signals can calm down. And if 12 to 14 hours seems like a lot, you probably slept for 8 hours. And if you didn't eat 3 hours before bed, you got 11 hours, have breakfast 10 hours or 2 later, you got your 14 hours, it's not that hard, you're not going to starve."

Part 1, hunger is not a math problem, it's a hormone problem

Part 1, hunger is not a math problem, it's a hormone problem. In my quest that was a hundred pounds, I found out that does not work, as has every person who's ever tried to lose weight sustainably that way.

"Part 1, hunger is not a math problem, it's a hormone problem. Before we talk about the fix, we need to talk about the mistake almost everyone makes. See, most people think the secret to weight loss is eating less or counting calories. In my quest that was a hundred pounds, I found out that does not work, as has every person who's ever tried to lose weight sustainably that way."

That hormone tells your brain, food is here, you can slow down

One of the most important of those is GLP1, when you eat specific cells and your intestine are supposed to release GLP1 into your bloodstream. That hormone tells your brain, food is here, you can slow down.

"One of the most important of those is GLP1, when you eat specific cells and your intestine are supposed to release GLP1 into your bloodstream. That hormone tells your brain, food is here, you can slow down. It helps your pancreas release insulin in a healthy way. It slows stomach emptying just enough so you feel satisfied, not stuffed."

This is the piece that most people overlook

That means that the butarate can't send GLP1 signals to your brain because it's not there. And instead of feeling calm and satisfied after meals, you just feel hungry and as exhausted as you did before.

"That means that the butarate can't send GLP1 signals to your brain because it's not there. And instead of feeling calm and satisfied after meals, you just feel hungry and as exhausted as you did before. This is the piece that most people overlook. They think they're doing everything right, but the inner environment is still too inflamed or too depleted or too stressed to activate the chemistry that controls appetite."

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