Key Takeaway
Methylation is essential for neurotransmitter synthesis; impaired methylation is linked to depression and may respond to B-vitamin supplementation.
Summary
This review examines the relationship between methylation metabolism and mood disorders.
Adequate methylation is required for synthesis of serotonin, dopamine, and norepinephrine. Folate and B12 deficiencies impair methylation and are associated with increased depression risk.
Methods
- Literature review
- Neurotransmitter pathway analysis
- Clinical trial synthesis
- Mechanism discussion
Key Results
- Methylation affects mood chemistry
- B-vitamin status matters
- Supplementation may help
- Homocysteine as biomarker
Limitations
- Complex pathways
- Individual variation
- Not sole factor in mood