Association between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studies

Memon A, Rogers I, Fitzsimmons SMDD, et al. (2021) British Journal of Psychiatry
Title and abstract of Association between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studies

Key Takeaway

Meta-analysis confirms inverse association between lithium in drinking water and suicide rates across multiple populations.

Summary

This systematic review and meta-analysis examined the relationship between naturally occurring lithium in drinking water and suicide rates.

Key findings:

  • Analyzed studies from multiple countries (Japan, Austria, Greece, Texas, England)
  • Consistent inverse association between lithium levels and suicide rates
  • Effect observed across different populations and methodologies
  • Suggests even trace lithium has mood-stabilizing effects

Implications:

  • Supports lithium's mood-stabilizing properties at very low doses
  • Questions whether supplementation could provide similar benefits
  • Raises public health considerations

Clinical significance:

Provides epidemiological support for low-dose lithium's potential mood benefits, though extrapolating to supplementation requires caution.

Related Interventions

Related Studies

Source

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DOI: 10.1192/bjp.2020.128