Key Takeaway
Analysis of 27 studies (700+ patients) found carboxytherapy effective for cellulite and stretch marks, though no treatment is fully effective for striae.
Summary
This systematic review analyzed 27 studies with over 700 pooled cases examining carboxytherapy for aesthetic applications including cellulite, stretch marks, facial rejuvenation, and localized fat reduction.
The review found generally positive results across applications, with the strongest evidence for stretch marks and cellulite. However, the authors noted significant heterogeneity in protocols and outcome measures across studies.
Methods
- Systematic literature search across major databases
- Included clinical trials and case series
- Analyzed studies on cellulite, striae, facial rejuvenation, scars, and localized fat
- Assessed study quality and outcomes
Key Results
- 27 studies included (>700 cases)
- Most studies showed clinical improvement
- Histological improvements in collagen organization documented
- Best evidence for striae distensae and cellulite
- Variable protocols across studies (6-10 sessions typical)
Limitations
- Heterogeneous study designs and protocols
- Many studies lacked control groups
- Variable outcome measures
- Most studies had small sample sizes
- No treatment fully effective for striae