Key Takeaway
Weekly carboxytherapy sessions significantly reduced periorbital hyperpigmentation across lateral, middle, and medial regions (p<0.01).
Summary
This single-arm clinical trial evaluated carboxytherapy for periorbital hyperpigmentation (dark under-eye circles) in 20 Iranian patients with symmetric dark circles.
Patients received weekly intradermal CO2 injections for 4 weeks. Treatment involved 10-20 mL of CO2 at 20 mL/min at 15°C temperature.
Methods
- 20 patients with symmetric periorbital hyperpigmentation
- 4 weekly sessions of intradermal carboxytherapy
- CO2 volume: 10-20 mL per session
- Flow rate: 20 mL/min
- Temperature: 15°C
- Standardized photography and clinical assessment
Key Results
- Significant reduction in hyperpigmentation (p<0.01) in:
- Lateral region (p=0.002)
- Middle region (p=0.001)
- Medial region (p=0.001)
- Total response rate: 20%
- Patient satisfaction was high
- Improvements visible after 3rd session
Limitations
- Small sample size (n=20)
- No control group
- Short follow-up period
- Single ethnic population
- Total response rate of 20% is modest