Beneficial effects of a higher-protein breakfast on the appetitive, hormonal, and neural signals controlling energy intake regulation in overweight/obese, 'breakfast-skipping,' late-adolescent girls

Leidy HJ, Ortinau LC, Douglas SM, Hoertel HA (2013) American Journal of Clinical Nutrition
Title and abstract of Beneficial effects of a higher-protein breakfast on the appetitive, hormonal, and neural signals controlling energy intake regulation in overweight/obese, 'breakfast-skipping,' late-adolescent girls

Key Takeaway

A high-protein breakfast (35g) reduced hunger, increased fullness, and decreased evening snacking compared to skipping breakfast or eating a normal-protein breakfast in overweight adults.

Summary

This randomized crossover study examined how breakfast protein content affects appetite, hormonal responses, and brain activity related to food cues in overweight/obese young adults who habitually skipped breakfast.

Methods

  • Randomized crossover design
  • 20 overweight/obese young adults (18-20 years)
  • Three conditions: skip breakfast, normal protein (13g), high protein (35g)
  • Measured appetite, hormones (ghrelin, PYY), and fMRI brain responses
  • 6-day testing periods per condition

Key Results

  • High-protein breakfast reduced hunger throughout the day
  • Increased fullness and satiety hormones (PYY)
  • Reduced evening snacking on high-fat foods
  • fMRI showed reduced brain activation in reward-driven eating regions
  • Effects persisted throughout the day, not just post-meal

Figures

Limitations

  • Short duration (6 days per condition)
  • Young adult population only
  • Controlled laboratory setting
  • May not generalize to all populations

Related Interventions

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Source

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DOI: 10.3945/ajcn.112.053116