A ketone ester drink lowers human ghrelin and appetite

Stubbs BJ, Cox PJ, Evans RD, Cyrber P, Clarke K, Sherwood L (2018) Obesity
Title and abstract of A ketone ester drink lowers human ghrelin and appetite

Key Takeaway

Ketone ester consumption acutely reduced ghrelin levels and subjective hunger in healthy adults, suggesting potential appetite-suppressing effects.

Summary

Study examining the acute effects of exogenous ketone consumption on appetite hormones and subjective hunger.

Methods

  • Randomized crossover design
  • 15 healthy adults
  • Ketone ester vs isocaloric dextrose
  • Measured ghrelin, hunger, and fullness

Key Results

  • Significant reduction in plasma ghrelin
  • Reduced subjective hunger ratings
  • Increased fullness perception
  • Effects lasted ~2-4 hours
  • Dose-dependent response

Figures

Limitations

  • Acute study only
  • Small sample size
  • Single dose administration
  • Long-term effects unknown

Related Interventions

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Source

View on PubMed →

DOI: 10.1002/oby.22051