Key Takeaway
Systematic review of 12 publications found CBD shows promise for chronic pain management with a favorable safety profile, though more rigorous RCTs are needed
Summary
This systematic review evaluated the efficacy, safety, and regulatory landscape of CBD for chronic pain. Five databases were searched, applying inclusion criteria for adults with pain lasting over 3 months. Twelve publications were eligible, suggesting CBD may be effective for chronic pain with acceptable safety.
Methods
Systematic review following PRISMA 2020 checklist. Five databases searched. Inclusion criteria: adults >18 years, pain >3 months. 2,298 articles identified, 12 eligible for review. Published in Cureus.
Key Results
CBD demonstrated potential efficacy for chronic pain across included studies. Safety profile was generally favorable with mild adverse effects. Regulatory landscape remains complex and varies by jurisdiction.
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Limitations
Only 12 publications met criteria. Heterogeneous study populations and pain conditions. Variable CBD formulations and doses. Limited high-quality RCTs. Regulatory barriers affect research quality. Publication bias possible.