Summary
Dr. Judith Campisi discusses cellular senescence, its role in aging, and potential therapeutic interventions.
Key Points
- Senescent cells accumulate with age
- They secrete inflammatory factors (SASP)
- Senolytics can clear senescent cells
- Senescence has beneficial roles too
- Balance is key in targeting senescence
- Research on senolytics advancing
Key Moments
Cellular Senescence: How To
Welcome back to another Scienterific episode of the Found My Fitness podcast. Today's guest is Dr.
"Welcome back to another Scienterific episode of the Found My Fitness podcast. Today's guest is Dr. Judith Campisi, a professor of biogerontology at the Buck Institute for Research on Aging and a co-editor-in-chief of the Aging Journal."
Cellular Senescence: Benefits
Some people have argued that with age, the barrier in your gut breaks down slightly, not enough to cause bacteria to invade your tissues, but enough to enable bacterial products to leak into your bloodstream.
"And now you can imagine that those cells, as they build up, they start to drive the pathologies that we associate with aging. Probably also start to cause more cellular senescence."
Cellular Senescence: Benefits
That's pretty funny. I kind of, I've always been curious about what tissues, if certain tissues accumulate more senescent cells than other tissues, including in the brain.
"Maybe we can talk a little bit about the mechanisms that lead to cellular senescence. I mean, we mentioned inflammation sort of...you mentioned it's a stress response. It's just distress. But, you know, specifically..."
Cellular Senescence: Benefits
Do the mitochondrial-induced senescent cells, they produce the growth factors that affect stem cell growth? They produce some growth factors, yes.
"Do the mitochondrial-induced senescent cells, they produce the growth factors that affect stem cell growth? They produce some growth factors, yes. They produce, for example, amfiregulin, which is an EGF-like growth factor. So they do. They do."
Resveratrol: Benefits
The error bars get larger and larger and larger. We don't know whether it's malleable, meaning we don't know whether you can make things less variable or more variable.
"So that says there is stochastic variation that's not due to genetic differences that causes identical animals to have some with a high burden of senescent cells, some with a low burden of senescent cells."
