Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells

Hachmo Y, Hadanny A, Abu Hamed R, et al. (2021) Aging
hyperbaric-oxygen-therapy hbot longevity telomeres senescent-cells
Title and abstract of Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells

Key Takeaway

60 HBOT sessions increased telomere length by 20-38% and decreased senescent cells by up to 37% in adults over 64.

Summary

This landmark prospective trial from Tel Aviv University examined the effects of 60 daily hyperbaric oxygen sessions (2.0 ATA, 90 min) on telomere length and cellular senescence in 35 healthy adults aged 64+.

Key findings:

  • T helper cell telomeres: +20%
  • T cytotoxic cell telomeres: +25%
  • Natural killer cell telomeres: +38%
  • B cell telomeres: +29%
  • Senescent T helper cells: -37%
  • Senescent T cytotoxic cells: -11%

The study demonstrated that HBOT can reverse two hallmarks of aging, telomere shortening and cellular senescence, through the hyperoxia-hypoxia paradox.

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DOI: 10.18632/aging.202188