Effects of Intermittent Hypoxia in Training Regimes and in Obstructive Sleep Apnea on Aging Biomarkers and Age-Related Diseases: A Systematic Review

Tessema B, Sack U, König B, Serebrovska Z, Egorov E (2022) Frontiers in Aging Neuroscience
Title and abstract of Effects of Intermittent Hypoxia in Training Regimes and in Obstructive Sleep Apnea on Aging Biomarkers and Age-Related Diseases: A Systematic Review

Key Takeaway

Intermittent hypoxia, similar to breath-hold training, may activate cellular longevity pathways including effects on telomere maintenance.

Summary

Research examining intermittent hypoxia effects on cellular aging markers.

Methods

  • Review of hypoxia research
  • Telomere biology focus
  • Cellular mechanisms
  • Longevity pathway analysis

Key Results

  • Hypoxia activates HIF-1α pathway
  • Potential telomere effects
  • Stress adaptation response
  • Hormetic mechanism proposed
  • Links to breath-hold training

Figures

Limitations

  • Mostly mechanistic studies
  • Human data limited
  • Optimal exposure unclear
  • Individual variation likely

Related Interventions

Related Studies

Source

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DOI: 10.3389/fnagi.2022.878278