Huberman Lab

Essentials: Using Your Nervous System to Enhance Your Immune System

Huberman Lab with Andrew Huberman 2025-09-25

Summary

Cyclic hyperventilation at the first sign of illness can reduce inflammation and shorten recovery time. Elevating your feet during sleep optimizes the glymphatic system for better immune function, and nasal breathing keeps pathogens out while fermented foods strengthen your gut microbiome defenses.

Key Points

  • The immune system operates through three layers: mucus/microbiome barriers, innate immunity, and adaptive immunity
  • Practice nasal breathing and avoid touching eyes to support the first line of defense; consume fermented foods to enhance gut microbiota
  • Elevating feet during sleep optimizes the glymphatic system, enhancing waste removal and immune function during rest
  • Early symptom recognition combined with cyclic hyperventilation can reduce stress-induced inflammation and support immune response
  • Maintaining a positive outlook directly influences immune function through dopamine signaling and nervous system state
  • Understanding sickness behavior reveals how the vagus nerve orchestrates protective immune responses
  • Strategic use of supplements like spirulina and targeted breathing protocols can speed recovery

Key Moments

Nasal breathing protects your microbiome: distinct microbial communities from nose to gut

Different body regions (eyes, mouth, nose, gut) host distinct microbiomes.

"It's well established that there are healthy microbiota that live all along that length and they differ along that length."

Related Interventions

Featured Experts