Huberman Lab
Stop Chasing Pain
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Nasal Breathing

37 episodes A

Nasal breathing and breathwork science. Why nose breathing matters for sleep, performance, and health. Featuring James Nestor, Patrick McKeown, and Huberman.

Breathing through your nose instead of mouth for nitric oxide production, better oxygen delivery, and improved sleep

Nasal breathing is one of the most underrated health interventions. Your nose isn't just an air filter - it's a nitric oxide factory. Breathing through your nose produces 15-20% of your body's nitric oxide, a molecule that dilates blood vessels, kills pathogens, and improves oxygen delivery to tissues.

The research is clear: mouth breathing is associated with sleep apnea, dental problems, facial development issues in children, and reduced exercise performance. Nasal breathing improves all of these while costing nothing.

If you're breathing through your mouth during the day or sleeping with your mouth open, fixing this is one of the highest-ROI changes you can make. Pairs perfectly with mouth taping for sleep.

Science & Mechanisms

Nitric Oxide Production:

The paranasal sinuses continuously produce nitric oxide (NO). When you breathe through your nose, this NO is carried into the lungs where it: - Dilates blood vessels (vasodilation) - Improves oxygen uptake in alveoli - Kills bacteria, viruses, and fungi - Regulates blood pressure

Mouth breathing bypasses this entirely - you get zero nasal NO.

The Bohr Effect & Oxygen Delivery:

Nasal breathing naturally slows respiration and increases CO2 tolerance. Higher CO2 levels shift the oxygen-hemoglobin dissociation curve rightward (Bohr effect), meaning hemoglobin releases MORE oxygen to tissues.

Paradoxically, breathing less (through your nose) delivers more oxygen than breathing more (through your mouth).

Key Research:

  • Lundberg et al. (1995): Discovered high NO concentrations in nasal airways
  • Recinto et al. (2017): Nasal breathing during exercise reduced ventilation rate by 22% with equal performance
  • Multiple studies link mouth breathing to sleep disordered breathing, dental malocclusion, and reduced quality of life

Mechanisms Summary:

  1. Nitric oxide delivery - Antimicrobial, vasodilating, bronchodilating
  2. Air conditioning - Filters particles, humidifies to 95-100%, warms to body temperature
  3. CO2 retention - Improves oxygen delivery via Bohr effect
  4. Parasympathetic activation - Nasal airflow stimulates calming nervous system response
  5. Reduced over-breathing - Prevents chronic hyperventilation

Effect Sizes:

  • Nitric oxide: 6x higher concentration in nasal vs. oral breathing
  • Exercise efficiency: ~10-20% reduction in ventilation at same workload
  • Sleep quality: Significant improvement when mouth breathing corrected

Episodes

1
Huberman Lab
Essentials: Breathing for Mental & Physical Health & Performance | Dr. Jack Feldman
Huberman Lab Andrew Huberman 2025-11-13

Slow, controlled breathing directly reduces anxiety by activating specific neural pathways - this isn't placebo, it's brain circuitry. Box breathing and diaphragmatic techniques...

2
Huberman Lab
Dr. Jack Feldman: Breathing for Mental & Physical Health & Performance
Huberman Lab Jack Feldman 2022-01-10

Mouth breathing causes structural and health problems; nasal breathing filters air and produces nitric oxide. Slow breathing at 5-6 breaths per minute optimizes CO2 tolerance. M...

3
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SCP Podcast Mini Series, Episode 42: Easy Breathing for Chillaxing and Relaxing
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Dr. Perry Nickelston shares a simple daily breathing ritual designed to calm the nervous system and support the body's healing processes. He breaks down the top three physiologi...

4
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5
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How to Breathe Correctly for Optimal Health, Mood, Learning & Performance
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6
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9
Find Your Daily Calm
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This is a re-release of the Find Your Daily Calm episode featuring a guided Buteyko reduced breathing exercise with Dr. Charles Edward Florendo, Southeast Asia's first physician...

10
Align Podcast
Patrick Mckeown: Nose Breathing, Tongue Strength, Over-Breathing | Ep. 245
Align Podcast Patrick McKeown 2019-09-23

Aaron Alexander of the Align Podcast interviews Patrick McKeown, author of The Oxygen Advantage, in a wide-ranging conversation that begins with a philosophical discussion about...

11
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How to Prevent & Treat Colds & Flu
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Andrew Huberman explains the biology of colds and influenza -- how these viruses are transmitted, how the immune system responds, and evidence-based protocols for prevention and...

12
Breathe Better Sleep Better Live Better Podcast
Buteyko Breathing with Patrick Mckeown
Breathe Better Sleep Better Live Better Podcast Patrick McKeown 2013-04-27

Dr. Stephen Park, an ENT physician specializing in obstructive sleep apnea, interviews Patrick McKeown, an internationally renowned Buteyko expert and author. The episode focuse...

13
Huberman Lab
Essentials: Using Your Nervous System to Enhance Your Immune System
Huberman Lab Andrew Huberman 2025-09-25

Cyclic hyperventilation at the first sign of illness can reduce inflammation and shorten recovery time. Elevating your feet during sleep optimizes the glymphatic system for bett...

14
Stop Chasing Pain
Your Tongue Matters in Chronic Pain and Fight or Flight
Stop Chasing Pain Dr. Perry Nickelston 2026-01-17

Dr. Perry Nickelston highlights the overlooked role of tongue posture and function in chronic pain and nervous system regulation. He explains how the tongue connects directly to...

15
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16
Vitamins D & K Plus Nasal Breathing to Change Your Sleep, Airway Health and More | Joel Gould, DDS
High Intensity Health Joel Gould, DDS 2023-11-01

Vitamins D & K Plus Nasal Breathing to Change Your Sleep, Airway Health and More. Guest Joel Gould, DDS joins the discussion to share evidence-based insights on this topic, cove...

17
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In this Huberman Lab Essentials episode, Andrew Huberman explores the science of chemical sensing -- how smell, taste, and chemical signals from other humans shape our biology a...

18
Age Less / Live More
192: Buteyko Breathing - Is C02 Your Friend?
Age Less / Live More Sasha Yakovleva 2016-03-03

Lucas Rockwood of the Yoga Talk Show (Age Less / Live More) interviews Sasha Yakovleva, executive director of the Breathing Center and a Buteyko breathing normalization expert. ...

19
On Purpose with Jay Shetty
Wim Hof ON: The One Simple Method To Improve Your Focus, Strength and Confidence
On Purpose with Jay Shetty Wim Hof 2020-11-16

Jay Shetty interviews Wim Hof about the intersection of ancient wisdom and modern science behind the Wim Hof Method. Wim shares stories from the Upanishads and Mahabharata to il...

20
The Holistic Navigator
You're Breathing Wrong: The Buteyko Breathing Method
The Holistic Navigator 2019-06-14

Host Ed Jones of The Holistic Navigator introduces Buteyko breathing to listeners, sharing his personal journey with the technique over several years of working with a Buteyko p...

21
Meditation with Raphael
Buteyko Breathing method: Anxiety Free !
Meditation with Raphael 2020-02-28

Host Raphael of the Meditation with Raphael podcast discusses the Buteyko breathing method as a practical technique for managing anxiety. He learned about the method from a book...

22
Soaring Child: Thriving with ADHD
127: Buteyko Breathing with Dr. Miles Nichols
Soaring Child: Thriving with ADHD Dr. Miles Nichols 2024-09-26

Host Dana Kay of the Soaring Child podcast welcomes back Dr. Miles Nichols, a functional medicine expert and founder of the Medicine with Heart Clinic, to discuss how Buteyko br...

23
The Connected Yoga Teacher Podcast
062: Buteyko Breathing with Steve Donald
The Connected Yoga Teacher Podcast Steve Donald 2018-04-30

Host Shannon Crow of the Connected Yoga Teacher podcast interviews Steve Donald, a Buteyko educator who took the first Buteyko educator training in Canada in 2006. Steve was dra...

24
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How to Improve Your Teeth & Oral Microbiome for Brain & Body Health | Dr. Staci Whitman
Huberman Lab Dr. Staci Whitman 2025-03-24

Andrew Huberman hosts functional dentist Dr. Staci Whitman for a deep dive into oral health as a pillar of whole-body wellness. They discuss how common oral care products — incl...

25
Modern Wisdom
#1049 - Dr Jay Wiles - A Masterclass in Improving Your HRV
Modern Wisdom Dr. Jay Wiles 2026-01-22

Dr. Jay Wiles, Chief Health & Performance Officer at Ohm Health and HRV researcher, joins Chris Williamson for a masterclass on heart rate variability. The episode covers what H...

26
Find Your Daily Calm
Relaxing Buteyko Breathing Method
Find Your Daily Calm Dr. Charles Edward Florendo 2025-05-28

This episode of Find Your Daily Calm features a guided Buteyko reduced breathing exercise led by Dr. Charles Edward Florendo, Southeast Asia's first and only physician certified...

27
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How to Improve Oral Health & Its Critical Role in Brain & Body Health
Huberman Lab Andrew Huberman 2024-02-12

Andrew Huberman provides a deep dive into oral health, explaining how the mouth serves as a gateway to whole-body health -- with poor oral hygiene linked to increased risk of ca...

28
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PNTV: The Oxygen Advantage by Patrick McKeown
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Brian Johnson presents a Philosopher's Notes TV book review of Patrick McKeown's The Oxygen Advantage, distilling the book into five key ideas. Brian shares that this book, alon...

29
Yoga Research & Beyond
Y&B #62 - Buteyko Breathing and Asthma
Yoga Research & Beyond Catherine Cowie 2017-11-28

Hosts Ariana Rabinovich and Catherine Cowie of the Yoga Research and Beyond podcast take a science-first look at the Buteyko breathing technique, reviewing a 2005 study publishe...

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32
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Interview: The Oxygen Advantage with Patrick McKeown
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35
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Wim Hof, The Iceman: Hack Your Biochemistry | E175
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Hala Taha interviews Wim Hof about his philosophy, his origin story, and the practical methods behind his extreme cold exposure and breathing techniques. Wim explains how modern...

36
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Fitness Toolkit: Protocol & Tools to Optimize Physical Health
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Build your weekly fitness around 150-200 minutes of zone 2 cardio (conversational pace, nasal breathing) plus strength training. Alternate emphasis every 10-12 weeks. Long zone ...

37
ZOE Science & Nutrition
The 4 breathing secrets that will transform your health today | James Nestor
ZOE Science & Nutrition 2026-02-26

James Nestor, author of Breath, shares findings from his self-experiment where plugging his nose for 10 days caused blood pressure spikes, fragmented sleep, and cognitive declin...

Related Research

Effects of Nasal and Oral Breathing on Respiratory Muscle and Brain Function: A Review.
Bayrak Ö, Polastri M, Pehlivan E (2025)
Nasal breathing activates more brain regions during cognitive tasks (15 vs 10 areas), enhances default mode network connectivity, and produces more efficient diaphragmatic breathing compared to oral breathing.
Mouth Closure and Airflow in Patients With Obstructive Sleep Apnea: A Nonrandomized Clinical Trial.
Yang H, Huyett P, Wang T, et al. (2024)
Mouth closure (via lip taping) during sleep reduced oral airflow and AHI in a subset of OSA patients, particularly those with higher baseline oral breathing.
The Impact of Mouth-Taping in Mouth-Breathers with Mild Obstructive Sleep Apnea: A Preliminary Study
Lee YC, Lu CT, Cheng WN, Li HY (2022)
Mouth taping during sleep reduced snoring severity and improved mild obstructive sleep apnea in adults who were primarily mouth breathers.
Effects of respiratory training on obstructive sleep apnea: systematic review and meta-analysis.
Cavalcante-Leão BL, de Araujo CM, Ravazzi GC, et al. (2022)
Respiratory muscle training significantly reduces AHI and improves oxygen saturation in obstructive sleep apnea patients.
Breathing Re-Education and Phenotypes of Sleep Apnea: A Review.
McKeown P, O'Connor-Reina C, Plaza G (2021)
Breathing re-education focusing on nasal breathing, slow breathing rate, and diaphragmatic activation addresses multiple OSA phenotypes and may reduce disease severity.
Proposal for a screening questionnaire for detecting habitual mouth breathing, based on a mouth-breathing habit score
Sano M, Sano S, Kato H, Arakawa K, Arai M (2019)
Mouth breathing during sleep is associated with poorer sleep quality, increased snoring, and reduced daytime alertness.