Summary
Rhonda Patrick covers sulforaphane and its effects on cancer, mortality, aging, brain and behavior, heart disease & more. Key topics include sulforaphane activates nrf2 pathway; broccoli sprouts are best source; myrosinase enzyme needed for conversion.
Key Points
- Sulforaphane activates Nrf2 pathway
- Broccoli sprouts are best source
- Myrosinase enzyme needed for conversion
- Anti-cancer properties documented
- Brain health benefits observed
- Practical consumption strategies
Key Moments
Sulforaphane: Cancer
Smokers who consumed at least four and a half servings of raw cruciferous vegetables a month had a 55% reduction in lung cancer risk compared with those who consume less than two and a half...
"Smokers who consumed at least four and a half servings of raw cruciferous vegetables a month had a 55% reduction in lung cancer risk compared with those who consume less than two and a half servings per month."
Liver Support Discussion
This gene makes an enzyme that has many protective functions, including detoxification of certain compounds, preventing them from damaging cells, and even more interestingly, protecting a very important tumor suppressor gene called p53 from being...
"This gene makes an enzyme that has many protective functions, including detoxification of certain compounds, preventing them from damaging cells, and even more interestingly, protecting a very..."
Blood Brain Barrier Discussion
This increase in NRF2's activity is important because NRF2 regulates over 200 genes, many of which affect cellular aging. It protects from cancer, which is an age-related disease by inactivating carcinogens and increasing their excretion.
"It deactivates inflammatory gene and activates antioxidant genes, which also protect DNA from damage that can lead to cancer, but also slow cellular aging in general. It does this by lowering the amount of damage that accumulates within cells."
Thyroid Health: Diet
This enzyme, which is released when the plant matter is crushed or chewed, unfortunately is heat sensitive. This is where a lot of people get into trouble.
"Most evidence indicates that this may only be a problem under conditions of severe iodine deficiency, which is not common."
