Summary
Rhonda Patrick covers jed fahey, sc.d. on isothiocyanates, the nrf2 pathway, moringa & sulforaphane supplementation. Key topics include sulforaphane activates nrf2 pathway; broccoli sprouts are best source; myrosinase enzyme needed for conversion.
Key Points
- Sulforaphane activates Nrf2 pathway
- Broccoli sprouts are best source
- Myrosinase enzyme needed for conversion
- Anti-cancer properties documented
- Brain health benefits observed
- Practical consumption strategies
Key Moments
Sulforaphane: Cancer
In my last podcast, I talked about the effects of a group of compounds known as isothiocynates that are produced by the brassica family of vegetables, including broccoli, kale, cauliflower, and so many others.
"What's more is we realized that sulforaphane is not what's present in the intact plant. So what's present in the plant is something called glucoraphanin, and that is a thioglucose-conjugated..."
Gut Microbiome: Diet
They're one of a number of companies that have a decent, I shouldn't say that have a decent one.
"They're one of a number of companies that have a decent, I shouldn't say that have a decent one. They're probably, you know, if you put this on a webinar, there are probably going to be 10 companies that say, we have a decent one too."
Alzheimer Prevention Discussion
Since we got our grant, there's a very interesting and I think quite important publication from Tom Mestelli's group at the NIH showing that, in fact, NRF2 is very intimately related to this process in...
"Since we got our grant, there's a very interesting and I think quite important publication from Tom Mestelli's group at the NIH showing that, in fact, NRF2 is very intimately related to this process in progeria."
Sulforaphane: Cancer
One thing that I can tell you is that in the quest for that answer, quite recently, Kitty Stevenson, who works here with us, and I started looking at the ability of sulforaphane to inhibit...
"Biomarker rich, then there's a washout period, and then everybody goes on the sulforaphane product, the Abmacol, for another 15 weeks. Dr. Hua Liu and I, she's doing most of the biomarker work here at Hopkins."
Alzheimer Prevention Discussion
The supposition is that markers of NRF2 activation are going to go up, and heat shock protein markers are going to go up.
"The supposition is that markers of NRF2 activation are going to go up, and heat shock protein markers are going to go up. We'll see. Right. Well, I mean, it's been shown in people that don't have autism that are given sulforaphane, at least."
Sulforaphane: Cancer
Another question, just to get back to some of what you were initially saying about how this plant, which is growing in some of these tropical regions and more developed nations and how it can...
"I suppose most mustard powder is okay, but it depends on how long it's been stored. I mean, as long as it develops a bite when you eat it, it should have active myrosinase. Yeah."
Sulforaphane: Cancer
is going to be flush from your system and the pharmacokinetics look like this and they're there, it's there, it appears, its metabolites appear and it's gone.
"Well, indeed. And I'm just wondering if there's anything we were thinking about before we sat down together that we sort of missed. And yeah, I've got one. We missed something. Urinary health."
Cancer Prevention Discussion
is going to be flush from your system and the pharmacokinetics look like this and they're there, it's there, it appears, its metabolites appear and it's gone.
"Well, indeed. And I'm just wondering if there's anything we were thinking about before we sat down together that we sort of missed. And yeah, I've got one. We missed something. Urinary health."
