Huberman Lab

Essentials: Food & Supplements for Brain Health & Cognitive Performance

Huberman Lab with Andrew Huberman 2025-09-11

Summary

Three supplements with solid evidence for brain health: EPA omega-3s (1.5-3g daily) for neuronal membranes, creatine (5g daily) as brain fuel for mood and cognition, and choline (500mg-1g daily) for focus via acetylcholine. Dark berries provide neuroprotective anthocyanins. You can rewire food cravings in 7-14 days with deliberate exposure.

Key Points

  • Structural brain health: the role of essential fatty acids and phospholipids in neuronal membrane integrity, with EPA omega-3 supplementation (1.5-3g daily)
  • Neurotransmitter support: choline's importance for acetylcholine production enabling focus and concentration (500mg-1g daily)
  • Cognitive enhancement: creatine supplementation (5g monohydrate daily) as brain fuel supporting frontal cortical circuits for mood and motivation
  • Neuroprotection via anthocyanins: evidence supporting dark berries (blueberries, blackberries) for brain-protective compounds
  • Appetite regulation: glutamine's potential to offset sugar cravings through gut neuron signaling
  • Psychology of food preference: three mechanisms shaping food choices with strategies for rewiring preferences within 7-14 days
  • Belief effects on metabolism: research showing beliefs about food composition directly influence physiological responses like insulin and glucose

Key Moments

Creatine

Creatine for brain function: 5g/day monohydrate as a cognitive fuel source

Creatine serves as a brain fuel source and supports neuronal function.

"What is the threshold level of creatine to supplement in order to get the cognitive benefit? Appears to be at least five grams per day."

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