Key Takeaway
Systematic review finding suggestive but not definitive evidence that magnesium supplementation may reduce subjective anxiety, with effects most pronounced in vulnerable populations.
Summary
This systematic review examined 18 studies investigating the relationship between magnesium supplementation and anxiety.
Key findings:
- Suggestive evidence for anxiolytic effects of magnesium
- Effects most pronounced in individuals with:
- Pre-existing anxiety
- Premenstrual syndrome
- Mild hypertension
- Combination with vitamin B6 may enhance effects
- Generally well-tolerated with few side effects
Limitations noted:
- Heterogeneous study designs
- Variable magnesium forms and doses
- Many studies in specific populations
Conclusion:
While evidence is suggestive rather than definitive, magnesium shows promise for anxiety management, particularly in those with suboptimal status.