Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

Summary

This clinical trial from Baylor College of Medicine tested glycine + NAC (GlyNAC) supplementation in older adults. After 16 weeks, participants showed:

• Corrected glutathione deficiency
• Reduced oxidative stress
• Improved mitochondrial function
• Better physical function measures

The combination addresses age-related decline in glutathione synthesis by providing both precursors.

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