Key Takeaway
NR supplementation (500mg twice daily) was well-tolerated in older adults, increased NAD+ by ~60%, and showed trends toward reduced blood pressure and arterial stiffness.
Summary
This randomized, double-blind, placebo-controlled crossover trial examined NR supplementation in healthy middle-aged and older adults.
Protocol:
- 24 lean, healthy adults (55-79 years)
- 500mg NR twice daily (1,000mg total) for 6 weeks
- Crossover design with placebo
Key findings:
- NAD+ in PBMCs increased ~60%
- Well-tolerated with no serious adverse events
- Trend toward reduced systolic blood pressure (-5 mmHg)
- Trend toward reduced arterial stiffness
- No significant changes in metabolic markers
Significance:
Established that oral NR can effectively raise NAD+ levels in humans and suggested cardiovascular benefits warranting larger trials.
Figures
Figure 1
Figure 2
Figure 3