Summary
Rhonda Patrick explores NAD+ in aging and the role of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) as precursors. Covers the science of NAD+ decline with age and supplementation strategies.
Key Points
- NAD+ declines with age
- NR and NMN as NAD+ precursors
- Comparison of different NAD+ boosters
- Mitochondrial function and aging
- Current research findings and limitations
Key Moments
NMN mitigates age-related decline in mice
Rhonda Patrick's deep dive on NAD precursors. Long-term NMN in mice improved muscle function, mitochondria, and energy metabolism.
"A long-term study found that dietary administration of nicotinamide mononucleotide mitigated the age-associated physiological decline in mice that have an accelerated aging phenotype."
Related Research
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
NR supplementation (500mg twice daily) was well-tolerated in older adults, increased NAD+ by ~60%, and showed trends toward reduced blood pressure and arterial stiffness.
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.
A dose-dependent RCT found that 300, 600, and 900 mg/day NMN safely increased blood NAD+ levels and improved walking endurance in healthy middle-aged adults over 60 days.
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men
250mg NMN daily for 12 weeks improved gait speed, grip strength, and NAD+ levels in healthy older men, suggesting functional benefits for aging muscle.
Related Interventions
In Playlists
NMN / NAD+ Precursors (14 episodes)
Peptides & Longevity Molecules (12 episodes)
Optimize Your NAD+ (11 episodes)
Boost Your Mitochondria (12 episodes)
