Summary
Rhonda Patrick examines the evidence on resveratrol as a longevity compound. Critically evaluates the research, separating hype from what the data actually shows about this popular supplement.
Key Points
- Resveratrol research overview
- Sirtuin activation claims examined
- Bioavailability challenges
- What the human studies actually show
- Practical recommendations
Key Moments
Sinclair's information theory of aging explained
David Sinclair proposes aging is loss of epigenetic information. The genome is digital and stable; the epigenome is analog and degrades.
"The epigenome is the reader of the genome and it's analog and very hard to maintain over 80 years. It's a loss of information. It has to be the key."
Fasting activates all four aging pathways
Fasting and caloric restriction affect AMP kinase, sirtuins, mTOR, and IGF-1 signaling, all of which can also be targeted by NAD precursors.
"The AMP kinase, the sirtuins, the mTOR, and IGF-1 insulin signaling, all those aging pathways certainly are affected by fasting and caloric restriction."
NAD boosters improve brain function in mice
NAD boosters help the brain in mouse models. NMN given to normal aging mice improved skeletal muscle and mitochondrial function.
"The NAD boosters also help the brain. So at least in mice, a couple of labs have shown this is working."
