Key Takeaway
250mg NMN daily for 12 weeks improved gait speed, grip strength, and NAD+ levels in healthy older men, suggesting functional benefits for aging muscle.
Summary
This randomized, placebo-controlled trial examined NMN's effects on physical function in healthy older men.
Protocol:
- 42 healthy older men (65+ years)
- 250mg NMN daily for 12 weeks
- Measured physical performance and blood NAD+ metabolites
Key findings:
- Blood NAD+ and related metabolites increased significantly
- Gait speed improved in NMN group
- Grip strength improved
- No significant adverse effects
- Hearing and body composition unchanged
Significance:
Provided evidence that NMN supplementation may improve age-related physical decline, with measurable functional improvements in gait and strength - meaningful outcomes for aging populations.
Figures
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