Key Takeaway
Meta-analysis confirms accelerated TMS protocols are effective for depression with faster onset than traditional TMS.
Summary
This systematic review and meta-analysis evaluated accelerated TMS protocols for major depression.
Key findings:
- Accelerated protocols non-inferior to standard TMS
- Faster onset of clinical effects
- Comparable safety profile
- More practical for patients (less time commitment)
Protocols analyzed:
- Multiple sessions per day
- Treatment courses of 2-5 days
- Various stimulation parameters
Advantages identified:
- Reduced treatment duration (days vs weeks)
- Lower patient burden
- Potentially faster return to function
- Suitable for acute settings
Clinical significance:
Validates the concept of accelerated TMS, paving the way for intensive protocols like SAINT to become standard care.
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