Paul Saladino MD Podcast
The Cabral Concept
Medical Medium Podcast
Dishing Up Nutrition
Intelligent Medicine | The Best of High Tech Medicine and Alternative Modalities

Raw Honey

5 episodes B

Episodes covering raw honey — protocols, research, and expert discussions.

Unprocessed honey for sleep support, blood sugar moderation, antimicrobial benefits, and as a healthier sweetener alternative

Raw honey is a functional food with genuine therapeutic properties backed by thousands of years of traditional use and modern clinical research. A comprehensive review of 48 clinical trials found beneficial effects on cardiovascular/metabolic markers, wound healing, and cough relief in children.

The sleep benefit is particularly interesting - honey may stabilize overnight blood sugar and contains tryptophan precursors. Some preliminary research suggests it may work as well as melatonin for sleep, though more studies are needed.

As a sweetener replacement, honey offers advantages: lower glycemic response than sugar, antimicrobial properties, and bioactive compounds absent in refined sugar.

A reasonable addition to a health-focused diet, especially for sleep support or replacing processed sweeteners. Choose raw, unfiltered varieties to preserve enzymes and bioactives. Manuka honey offers additional antimicrobial benefits but at much higher cost.

Science & Mechanisms

What Makes Raw Honey Different:

Raw honey is unheated, unpasteurized, and unfiltered. This preserves: - Enzymes (glucose oxidase, diastase) - Bee pollen - Propolis - Antioxidants (flavonoids, phenolic acids)

Regular commercial honey is heated and filtered, destroying many bioactive compounds.

Key Mechanisms:

1. Antimicrobial Properties:

  • Hydrogen peroxide production (via glucose oxidase)
  • Low pH (3.2-4.5) inhibits pathogens
  • High sugar content creates osmotic stress
  • Methylglyoxal in Manuka honey (additional antibacterial)

2. Blood Sugar Moderation:

  • GI of ~60 (medium, lower than sugar at 65)
  • Fructose-to-glucose ratio slows absorption
  • May improve insulin sensitivity over time
  • Better than sugar, but still a sugar

3. Sleep Support:

  • Stabilizes overnight blood sugar (prevents 3am wake-ups)
  • Contains tryptophan → serotonin → melatonin pathway
  • Glycogen replenishment for liver
  • University of Saskatchewan research: May rival melatonin

4. Wound Healing:

  • FDA-approved Manuka honey dressings exist
  • Antibacterial + promotes tissue regeneration
  • Reduces inflammation at wound site

Clinical Evidence (2023 Comprehensive Review):

48 trials, 3,655 subjects: - Cardiovascular/metabolic benefits when replacing sugar - Improved glucose tolerance - Effective for chemotherapy-induced mucositis - Superior to placebo for pediatric cough - Promotes wound healing

Episodes

1
Paul Saladino MD Podcast
245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast
Paul Saladino MD Podcast Mike Fave 2024-01-25

Paul Saladino and critical care RN Mike Fave discuss sugar and fructose, responding to claims made on a recent Huberman Lab podcast with Robert Lustig. They challenge specific p...

2
The Cabral Concept
2461: The Raw Honey Challenge (TWT)
The Cabral Concept 2022-11-01

Board-certified naturopath Dr. Stephen Cabral walks through the evidence behind raw honey as a functional food and medicine. He highlights that the Mayo Clinic recognizes raw ho...

3
Medical Medium Podcast
027 Raw Honey: Too Much Sugar?
Medical Medium Podcast 2022-08-24

The Medical Medium podcast tackles the common objection that raw honey is "too much sugar." The host argues that the fear of honey's sugar content is misplaced, driven by high-f...

4
Dishing Up Nutrition
Raw Honey vs Processed Honey - Ask a Nutritionist
Dishing Up Nutrition Monica Haas 2024-02-15

Licensed and registered dietitian Monica Haas breaks down the key differences between raw and processed honey. She explains that pasteurization at 160 degrees Fahrenheit destroy...

5
Intelligent Medicine | The Best of High Tech Medicine and Alternative Modalities
Leyla Weighs In: Honey Therapy--A Sweet Solution to Seasonal Allergies
Intelligent Medicine | The Best of High Tech Medicine and Alternative Modalities 2025-02-28

Registered dietitian nutritionist Leyla Muden reviews the evidence for using local raw honey as immunotherapy for seasonal allergies and allergic rhinitis. She cites specific cl...

Related Research

Efficacy and Safety of Honey Dressings in the Management of Chronic Wounds: An Updated Systematic Review and Meta-Analysis.
Tang Y, Chen L, Ran X (2024)
Honey dressings significantly shorten wound healing time, increase complete healing rates, and reduce bacterial load in chronic wounds compared to conventional dressings.
Use of honey in diabetic foot ulcer: Systematic review and meta-analysis.
Yildiz Karadeniz E, Kaplan Serin E (2023)
Honey-based wound care significantly improves healing rates and reduces wound size in diabetic foot ulcers compared to standard treatments.
Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis.
Abuelgasim H, Albury C, Lee J (2021)
Honey is superior to usual care for improving upper respiratory tract infection symptoms, particularly cough frequency and severity, and represents a widely available alternative to antibiotics.
Honey for acute cough in children
Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM (2018)
Cochrane review found honey probably reduces cough symptoms in children more effectively than placebo and diphenhydramine, and may be similar to dextromethorphan.
Honey and health: a review of recent clinical research
Samarghandian S, Farkhondeh T, Samini F (2017)
Comprehensive review found honey has antimicrobial, antioxidant, and wound-healing properties supported by clinical research.
Honey for nutrition and health: a review
Bogdanov S, Jurendic T, Sieber R, Gallmann P (2009)
Authoritative review establishing honey's nutritional composition and evidence-based health benefits, including antimicrobial and antioxidant effects.