Summary
Dr. Guido Kroemer discusses autophagy, caloric restriction, and their roles in longevity and disease prevention.
Key Points
- Autophagy clears damaged cellular components
- Fasting triggers autophagy
- Caloric restriction extends lifespan
- Spermidine induces autophagy
- Exercise activates autophagy
- Autophagy declines with age
Key Moments
Extended Fasting Discussion
Welcome back, Found My Fitness podcast listeners. Today's episode features Dr.
"Welcome back, Found My Fitness podcast listeners. Today's episode features Dr. Guido Cromer, who was a professor at the University of Paris, Descartes."
Autophagy: Fasting
Welcome back, Found My Fitness podcast listeners. Today's episode features Dr.
"And actually, the phenomenon is observed mostly in the context of stress. So cells, when they are stressed, will often undergo an autophagic reaction, which occurs before the cells die."
Sauna: Heat Shock
It has not been, to my knowledge, extrapolated to other organs. There's a fundamental difference between rodents and humans.
"And he observed that as a result of not eating during the day, there was more autophagy in the liver. So this result is intriguing. It has not been, to my knowledge, extrapolated to other organs. And it certainly requires more profound studies."
Time Restricted Eating: Fasting
It has not been, to my knowledge, extrapolated to other organs. There's a fundamental difference between rodents and humans.
"And he observed that as a result of not eating during the day, there was more autophagy in the liver. So this result is intriguing. It has not been, to my knowledge, extrapolated to other organs. And it certainly requires more profound studies."
Caloric Restriction Discussion
It has not been, to my knowledge, extrapolated to other organs. There's a fundamental difference between rodents and humans.
"And he observed that as a result of not eating during the day, there was more autophagy in the liver. So this result is intriguing. It has not been, to my knowledge, extrapolated to other organs. And it certainly requires more profound studies."
Autophagy: Fasting
You have similar examples in the embryonic development of the retina for retinal ganglion cells or the differentiation of macrophages from so-called M0 to M1 macrophages in which the cells change from oxidative phosphorylation, respiration...
"You have similar examples in the embryonic development of the retina for retinal ganglion cells or the differentiation of macrophages from so-called M0 to M1 macrophages in which the cells change..."
Caloric Restriction Discussion
So, in contrast to the official dogma that has been en vogue for several decades, chemotherapy is not just killing the cancer cells as if we used an antibiotic that specifically paralyzes the metabolism of...
"And it is exactly this process that makes cancer therapies efficient. So, in contrast to the official dogma that has been en vogue for several decades, chemotherapy is not just killing the cancer..."
Resveratrol Discussion
The protein acetylation, it seems like that. I know it's found in high concentrations in natto, the Japanese fermented soybean that doesn't taste that great.
"And one example that is well known is resveratrol contained in red wine that induces autophagy through this pathway."
Extended Fasting Discussion
You have similar examples in the embryonic development of the retina for retinal ganglion cells or the differentiation of macrophages from so-called M0 to M1 macrophages in which the cells change from oxidative phosphorylation, respiration...
"And in mice, you actually can give a combination of high-fat diets that usually would cause obesity with spermidine to reduce weight gain through mechanisms that we don't understand and that we..."
