FoundMyFitness
Modern Wisdom
The Tim Ferriss Show

The Longevity Playbook

12 episodes

Science-backed strategies for healthspan — exercise, heat and cold, fasting, and stress resilience.

Science-backed strategies for healthspan — exercise, heat and cold, fasting, and stress resilience.

Episodes

1
FoundMyFitness
#038 Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation
FoundMyFitness Dr. Guido Kroemer 2017-07-31

Dr. Guido Kroemer discusses autophagy, caloric restriction, and their roles in longevity and disease prevention.

2
Modern Wisdom
Dr Mike Israetel - Exercise Scientist's Masterclass On Longevity
Modern Wisdom Dr. Mike Israetel 2024-12-02

Dr. Mike Israetel examines the truth about extending lifespan. As technology advances, living much longer feels within reach - but what does the latest science actually reveal? ...

3
FoundMyFitness
#086 How Micronutrients & Exercise Ameliorate Aging | Dr. Rhonda Patrick
FoundMyFitness Rhonda Patrick 2024-03-06

Vigorous exercise is the best longevity drug we have—each VO2 max unit adds 45 days of life. Combine with vitamin D (40-60 ng/mL), magnesium (top consumers have 40% lower mortal...

4
The Tim Ferriss Show
Rhonda Patrick — Fasting, Lowering Dementia Risk, Sauna for Longevity
The Tim Ferriss Show Rhonda Patrick, Ph.D. 2025-07-23

Dr. Rhonda Patrick shares protocols for fasting, reducing dementia risk, and reversing heart aging. Discusses optimal sauna use for longevity (hotter is not always better) and s...

5
FoundMyFitness
#048 Sauna Use as an Exercise Mimetic for Heart and Healthspan
FoundMyFitness Rhonda Patrick 2019-09-16

Rhonda Patrick explores how sauna use mimics many of the benefits of exercise. Covers the cardiovascular, metabolic, and longevity benefits of heat exposure and optimal sauna protocols.

6
Modern Wisdom
Dr Peter Attia - Scientifically Proven Ways To Build Muscle & Boost Longevity
Modern Wisdom Dr Peter Attia 2024-04-15

Dr Peter Attia is a physician, longevity expert, podcaster and an author. There is essentially an unlimited amount of health advice available on the internet. Working out what i...

7
Huberman Lab
Supplements for Longevity & Their Efficacy | Dr. Peter Attia
Huberman Lab Dr. Peter Attia 2024-07-29

Andrew Huberman speaks with Dr. Peter Attia, a Stanford and Johns Hopkins-trained physician and host of The Drive podcast, about whether popular longevity supplements actually e...

8
The Peter Attia Drive
#206 - Exercising for longevity: strength, stability, zone 2, zone 5, and more
The Peter Attia Drive 2022-05-09

Peter Attia presents an early version of his centenarian decathlon framework, explaining how he developed the idea of backcasting from age 100 to determine what physical capabil...

9
Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Huberman Lab Andrew Huberman 2025-10-30

Skipping one meal daily activates sirtuins and autophagy without requiring extreme fasting - low glucose and insulin states trigger your longevity genes. NMN supplementation can...

10
FoundMyFitness
#098 How to Train According to the Experts
FoundMyFitness Brady Holmer 2025-02-03

Two years of consistent exercise can reverse roughly 20 years of cardiovascular aging in sedentary middle-aged adults. Muscle mass drops 8% per decade without resistance trainin...

11
FoundMyFitness
#084 The Longevity & Brain Benefits of Vigorous Exercise | Dr. Rhonda Patrick
FoundMyFitness Rhonda Patrick 2023-12-05

Each VO2 max unit adds roughly 45 days to your life expectancy, and two years of vigorous training can reverse 20 years of cardiac aging. The Norwegian 4x4 protocol (four 4-minu...

12
FoundMyFitness
#046 Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging
FoundMyFitness Dr. Elissa Epel 2019-06-10

Dr. Elissa Epel discusses telomeres and their role in aging with Rhonda Patrick. Covers how lifestyle factors influence telomere length and what this means for longevity.

Related Research

Markers of clinical and mitochondrial adaptation in response to moderate intensity continuous training: A systematic review and meta-analysis
Vabishchevich V, Smith RT, Bittel AJ (2026)
Across 14 studies (n=184), moderate-intensity continuous training significantly increased mitochondrial volume density (p<0.00001) and VO2max (p<0.0001), with modest gains in citrate synthase and MFN2, confirming Zone 2-type exercise drives meaningful mitochondrial adaptation.
Non-acute effects of passive heating interventions on cardiometabolic risk and vascular health
Maas LSRC, et al. (2025)
Meta-analysis of 20 RCTs found passive heating (sauna, hot water) improves cardiometabolic and vascular health outcomes.
Impact of different doses of cold water immersion on recovery from acute exercise-induced muscle damage
Wang H, et al. (2025)
Network meta-analysis of 55 RCTs found 10-15 min at 11-15°C optimal for reducing muscle soreness and damage markers.
Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes.
Hua Z, Yang S, Li J, et al. (2025)
Umbrella review of 40+ meta-analyses confirms intermittent fasting significantly reduces body weight, BMI, and fat mass with comparable metabolic improvements to continuous energy restriction.
Cardiorespiratory fitness, body mass index and mortality: a systematic review and meta-analysis.
Weeldreyer NR, De Guzman JC, Paterson C, et al. (2025)
Higher cardiorespiratory fitness is associated with lower all-cause mortality regardless of BMI, suggesting that fitness matters more than weight for longevity.
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis.
Ding D, Nguyen B, Nau T, et al. (2025)
A comprehensive Lancet meta-analysis confirms that higher daily step counts are associated with significantly lower risks of all-cause mortality, cardiovascular disease, cancer, and type 2 diabetes, with most benefits accruing by 8,000-10,000 steps per day.