Paul Saladino MD Podcast

Why I Changed My Mind About Hydrogen Water (with Tyler LeBaron)

Paul Saladino MD Podcast with Tyler LeBaron 2025-07-28

Summary

Tyler LeBaron explains how molecular hydrogen selectively targets only the most harmful free radicals while leaving beneficial ones alone. A six-month metabolic syndrome study showed improvements in glucose levels, HbA1c, and other markers from drinking hydrogen water.

Key Points

  • Why Paul changed his mind about hydrogen water
  • How hydrogen selectively targets harmful free radicals
  • Different from traditional antioxidant supplements
  • Study showing improvements in metabolic syndrome
  • Effects on glucose levels and HbA1c
  • Practical applications and dosing

Key Moments

3,000 publications and 200+ human studies on molecular hydrogen

Tyler LeBaron explains that molecular hydrogen has been studied in around 3,000 publications with over 200 human studies, covering Parkinson's disease, diabetes, metabolic syndrome, stroke, cancer, and Alzheimer's.

"far, over 200 human studies. Parkinson's"

24-week metabolic syndrome study shows improved glucose and HbA1c

A 24-week study with 60 subjects found that those drinking hydrogen water had improved glucose levels, improved HbA1c markers, decreased inflammation, and even weight loss compared to the placebo group.

">> it was a 24 week study."

Hydrogen selectively targets only the most toxic free radicals

Unlike traditional antioxidants, molecular hydrogen cannot neutralize beneficial free radicals. It can only react with the most toxic ones, making it a selective antioxidant that preserves healthy oxidative signaling.

"Hydrogen is very different because it actually does not have the physical chemical property to neutralize these other free radicals. Hydrogen can only react or only neutralize the most toxic free radicals."

Understanding molecular hydrogen chemistry

LeBaron clarifies the chemistry of hydrogen water, distinguishing between atomic hydrogen (a single proton and electron, which is a free radical) and molecular hydrogen (H2), which is the therapeutic form dissolved in water.

"this hydrogen because people get confused about what hydrogen water is right so so we got to follow this chemistry that's the first hydrogen now that hydrogen is just a proton and electron and and that's called atomic hydrogen and that's a free radical"

Related Research

Hydrogen Water: Extra Healthy or a Hoax?-A Systematic Review. Dhillon G (2024) · International journal of molecular sciences Systematic review of 25 human studies found encouraging preliminary results for hydrogen water across exercise, cardiovascular, metabolic, and cognitive outcomes.
Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis. Li Y (2024) · Frontiers in nutrition Meta-analysis confirmed molecular hydrogen significantly reduces exercise-induced oxidative stress markers (d-ROMs) and increases antioxidant capacity (BAP) in healthy adults.
Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study Mikami T (2020) · Canadian Journal of Physiology and Pharmacology Four weeks of hydrogen water consumption improved endurance capacity and reduced mental fatigue in healthy adults compared to placebo.
Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine Nicolson GL (2016) · International Journal of Clinical Medicine Systematic review of clinical trials found molecular hydrogen shows promise for oxidative stress-related conditions, though more rigorous trials are needed.
Molecular hydrogen in sports medicine: new therapeutic perspectives Ostojic SM (2015) · International Journal of Sports Medicine Review of molecular hydrogen showing potential for reducing exercise-induced oxidative stress and inflammation, with promising early human trial results.
Pilot study: effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes Aoki K (2014) · Medical Gas Research Hydrogen-rich water reduced blood lactate levels and improved muscle fatigue in elite athletes during acute exercise, suggesting potential recovery benefits.
The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis. Todorovic N (2023) · Pharmaceuticals (Basel, Switzerland) Meta-analysis found hydrogen-rich water significantly reduced total cholesterol and LDL-C in clinical populations, with larger effects in metabolically unhealthy individuals.
A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives Yıldız F (2025) · Biochemical and Biophysical Reports Comprehensive review of molecular hydrogen's mechanisms and therapeutic applications, supporting its potential as a novel therapeutic agent.

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