Key Takeaway
Meta-analysis showing creatine supplementation improves short-term memory and reasoning, with stronger effects in older adults and during stress or sleep deprivation.
Summary
Comprehensive meta-analysis examining creatine's effects on cognitive function across multiple studies.
Key findings:
- Significant improvements in short-term memory
- Enhanced reasoning and intelligence measures
- Stronger cognitive benefits in older adults (60+)
- More pronounced effects under stress or sleep deprivation
- Safe with no adverse cognitive effects reported
Mechanisms:
- Brain ATP buffering during high cognitive demand
- Neuroprotective effects against metabolic stress
- May support mitochondrial function in neurons
Clinical relevance:
Supports creatine use beyond athletic performance for cognitive health, particularly in aging populations and those under mental stress.
Figures
Figure 1