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#089 Why Exercise Intensity Matters for Longevity | CrossFit for Health 2024

FoundMyFitness with Rhonda Patrick 2024-04-08

Summary

Each unit increase in VO2 max adds roughly 45 days to life expectancy. The Norwegian 4x4 protocol (four 4-minute intervals at 95% max heart rate) is one of the most effective ways to boost it. For time-crunched people, exercise snacks of 1-2 minutes of high intensity three times daily correlate with 40% lower mortality.

Key Points

  • Each unit increase in VO2 max is associated with a 45-day increase in life expectancy
  • Moving from below-normal to high-normal fitness extends life approximately 3 years
  • Norwegian 4x4 protocol (four 4-minute intervals at 95% max heart rate) proves highly effective for VO2 max
  • HIIT outperforms moderate Zone 2 training for approximately 40% of people
  • Vigorous exercise increases blood shear stress, killing circulating tumor cells sensitive to mechanical forces
  • Exercise snacks (1-2 minutes high-intensity, 3x daily) correlate with 40% reduction in all-cause mortality
  • Sauna use (80-100C for 15-30 minutes, 2-3x weekly) mirrors aerobic exercise cardiovascular benefits

Key Moments

Sauna

Optimal sauna parameters, infrared vs. Finnish, and why hot baths also work

Rhonda covers the most robust sauna protocols for health, how infrared compares to traditional Finnish saunas, and why hot baths can be a valid.

"That's my disclosure. So focusing on exercise, it's going to be really vigorous exercise. We're going to talk about the importance of vigorous intensity exercise going like 80 percent max heart rate or more. We're going to talk about the brain benefits. We're going to talk about cardiovascular benefits, cancer a little bit, exercise snacks, then we're going to get into some muscle biology a little bit, the importance of protein, resistance training, and then into deliberate heat exposure and sauna and how that can synergize with both exercise and also with resistance training."

Going from below-average to normal VO2max adds ~2 years of life expectancy

The largest mortality benefit comes from moving out of the lowest VO2max tier.

"What type of aerobic exercise? I think it's pretty clear that high intensity interval training is one of the best ways to improve your VOT max. And particularly when you do longer intervals, yes, you can improve your your cardiorespiratory fitness with any type of aerobic exercise, particularly if you're starting from being sedentary and then going up, right. But there was a really important study that was published, a large, large population of people that showed people that are doing moderate intensity sort of zone two like training, you know, this is the kind of exercise that is more enjoyable, you can go for a run, and you can still have somewhat of a conversation, you're breathy. Those people are doing two and a half hours per week, they're meeting the guidelines. And yet they couldn't improve their VO2 max, about 40% of those people. So you're talking like half the population here until they added in some high intensity interval training."

Levine study: 2 years of vigorous exercise reversed heart stiffening in sedentary adults

Sedentary 50-year-olds who did 4-5 hours/week of aerobic exercise with vigorous intensity reversed cardiac stiffening, while the stretching control.

"They put them on one or two different exercise protocols. The other group did a high intensity, vigorous exercise workout program. And this was a two-year intervention study."
Sauna

Lighter weights build as much muscle as heavy if effort is high enough

Research from Stu Phillips and Brad Schoenfeld shows you can lift lighter weights and gain equivalent muscle mass and strength as long as you train.

"There's been a lot of animal studies on this. But there's now been some human data where people, you know, there's intervention trials where they're, you know, they basically immobilize one of their limbs for a period of weeks and then did some local heat exposure. And the local heat exposure prevented the disuse atrophy by like 40%. So, you know, I think that's a very relative, again, a very relevant weight for people that are injured or again, people that are older and they're experiencing a lot of muscle atrophy as well but there was also a very recent study and this is small so it needs to be repeated but people that were engaging in resistance training either just alone or then went into the sauna right after the resistance training they had greater gains in muscle mass if they went to sauna right after the resistance training compared to resistance training well they actually actually, it was biomarkers of it. So they didn't directly measure muscle mass. It was biomarkers. But anyways, I think it's an encouraging and promising area that, of course, I'm excited about and glad people are out there researching. But it's another possibility for a synergy between resistance training, between vigorous intensity exercise, your exercise program and then engaging in deliberate heat exposure as well so what are the parameters in a lot of these studies well a lot of the parameters in many of these studies are coming out of Finland the temperature is about 174 degrees Fahrenheit and the duration spent in the sauna is about 20 minutes and that's important because people that spent less than 20 minutes, like let's say they were in there for 11 minutes, they didn't have the robust effects."

Sauna mimics moderate cardio: comparable heart rate, blood pressure, and stroke volume effects

Sauna produces responses similar to moderate exercise: heart rate ~120 bpm, increased plasma volume, and cardiovascular benefits.

"And it's really like the studies have shown they're pretty comparable. So like when you're doing the activity, heart rate goes up, your blood pressure goes up while you're doing the activity, but then after the activity, whether it's exercise or sauna, you're getting blood pressure improvements, your resting heart rate is improved, and so these things are comparable. So really in some way, I would say engaging in deliberate heat exposure from the sauna is mimicking moderate intensity aerobic exercise. And there have been observational studies and some intervention studies we'll talk about in a second, but observational studies looking at people that are, and this is in Finland where saunas are pretty ubiquitous and most people are using them. So people in Finland that have sauna or using sauna and they exercise have a better cardiorespiratory fitness than people that exercise alone. And we're talking about the same volume of exercise. And these people are the ones that do that, but also sauna had a better cardiorespiratory fitness than people that only engaged in exercise."

Extreme endurance training and coronary calcification: risk is still lower overall

Elite endurance athletes may show slightly higher coronary calcification, but their overall cardiovascular death risk remains lower than committed.

"And I'm gonna defer to some of the experts on that where like Dr. Ben Levine, I think he, as far as I've heard from him is yes, like when you get to this like elite, elite athlete, endurance athlete level, I mean, there's some of the increased risks to do with like coronary calcification, whatever the, you know, the increased risks of that outcome are actually even lower, even if the coronary calcification is a little bit higher."
Sauna

Finnish vs. infrared sauna and whether temperatures above 200F help or hurt

Both sauna types work by raising core temperature and heart rate. Finnish saunas 4-7x/week at 174F show 66% reduced dementia risk.

"Those are great questions. All right. So to first address the mechanisms and is the beneficial effect of deliberate heat exposure that I've talked about today due to the increased heart rate, you know, the mimicking of, I would say, moderate intensity exercise. I think a lot of it comes down to that, the improvements in respiratory fitness and cardiovascular improvements, also the heat shock proteins as well. So the heat shock proteins are playing a role in the muscle, they're playing a role in the immune system, and they're also playing a role in the brain. So people that use finish saunas four to seven times a week at those temperature you know parameters that i mentioned have about a 66 reduction dementia risk um Alzheimer's disease risk so yeah i do think there is it really does come down to elevating the core body temperature and getting that heart rate up and and being being physically uncomfortable like you are when you're exercising um infraredrared saunas do work a little bit different. They're moving molecules in your body and heating you up a different way. There is evidence coming out of Dr. Ashley Mason's lab at UCSF, who I've been collaborating with, showing that a very rigorous infrared sauna protocol, it's like a heat bed where you head out."

Related Research

Sauna-Induced Body Mass Loss in Young Sedentary Women and Men Podstawski R (2015) · ScientificWorldJournal Single sauna session study showing acute cardiovascular benefits including improved heart rate variability and blood pressure responses in young adults.
Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients Wisløff U (2007) · Circulation The 4x4 Norwegian interval protocol improved VO2max by 46% in heart failure patients, vastly outperforming moderate continuous training.
Acute and short-term efficacy of sauna treatment on cardiovascular function: A meta-analysis. Li Z (2021) · European journal of cardiovascular nursing Meta-analysis of 16 studies found sauna acutely lowers blood pressure by 5-6 mmHg and over 2-4 weeks improves ejection fraction, walking distance, and vascular function in cardiovascular patients.
Sauna bathing is inversely associated with dementia and Alzheimer's disease in middle-aged Finnish men Laukkanen T (2017) · Age and Ageing Men using sauna 4-7 times weekly had 65% lower risk of dementia and 66% lower risk of Alzheimer's disease compared to once-weekly users.
Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women Laukkanen T (2019) · BMC Medicine Finnish study of 1,688 participants showing frequent sauna use (4-7x/week) associated with 40% lower risk of all-cause mortality compared to once weekly use.
Clinical Effects of Regular Dry Sauna Bathing: A Systematic Review. Hussain J (2018) · Evidence-based complementary and alternative medicine : eCAM A systematic review of 40 studies found that regular dry sauna bathing is generally well tolerated and associated with benefits for cardiovascular function, pain conditions, and overall well-being, with minimal adverse effects.
Does the Combination of Finnish Sauna Bathing and Other Lifestyle Factors Confer Additional Health Benefits? A Review of the Evidence. Kunutsor SK (2023) · Mayo Clinic proceedings Combining regular sauna bathing with other healthy lifestyle factors like exercise and good cardiorespiratory fitness provides additive reductions in cardiovascular and all-cause mortality beyond either alone.
Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence. Laukkanen JA (2019) · Mayo Clinic proceedings A comprehensive review finds that regular sauna bathing is associated with reduced risk of cardiovascular disease, neurocognitive disease, pulmonary conditions, and all-cause mortality, with benefits following a dose-response pattern.
Association between sauna bathing and fatal cardiovascular and all-cause mortality events Laukkanen T (2015) · JAMA Internal Medicine Finnish men using sauna 4-7 times per week had 40% lower all-cause mortality and 50% lower cardiovascular mortality compared to once-weekly users over 20 years.
Sauna Bathing and Incident Hypertension: A Prospective Cohort Study. Zaccardi F (2018) · American journal of hypertension Finnish men using sauna 4-7 times per week had a 47% lower risk of developing hypertension compared to once-weekly users over a median 24.7-year follow-up.
Effectiveness of High-Intensity Interval Training (HIT) and Continuous Endurance Training for VO2max Improvements: A Systematic Review and Meta-Analysis of Controlled Trials Milanović Z (2016) · Sports Medicine Comprehensive meta-analysis of 28 studies confirming HIIT produces significantly greater VO2max improvements than continuous endurance training.
High-intensity interval training and cardiorespiratory fitness in adults: An umbrella review of systematic reviews and meta-analyses. Poon ET (2024) · Scandinavian journal of medicine & science in sports HIIT produces large, consistent improvements in cardiorespiratory fitness across diverse adult populations, with effect sizes comparable to or greater than moderate-intensity continuous training.
Effects of moderate-intensity endurance and high-intensity intermittent training on anaerobic capacity and VO2max Tabata I (1997) · Medicine & Science in Sports & Exercise The Tabata protocol (20 sec on / 10 sec off x 8) improved both aerobic and anaerobic capacity in just 4 minutes per session.

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