The Cabral Concept
Paul Saladino MD Podcast
Huberman Lab
The Advisor with Stacey Chillemi
FoundMyFitness
Mitolife Radio

Which Supplements Actually Work

10 episodes

Cut through the noise — creatine, magnesium, electrolytes, and what the evidence actually supports.

Cut through the noise — creatine, magnesium, electrolytes, and what the evidence actually supports.

Episodes

1
The Cabral Concept
3632: Why Methylation Supplements Usually Backfire (TT)
The Cabral Concept 2026-01-15

Dr. Stephen Cabral explains why methylation supplements frequently backfire for people who take them without a foundational approach. He uses the analogy of B9 (methylfolate) an...

2
Paul Saladino MD Podcast
206. James DiNicolantonio: supplementation and nutrient deficiencies, eggs vs. bagels for weight loss, creatine and diet
Paul Saladino MD Podcast James DiNicolantonio 2023-03-14

Paul Saladino and pharmacist/author James DiNicolantonio cover creatine and carbs for post-exercise recovery, their views on fasting and keto, insulin resistance, magnesium supp...

3
Huberman Lab
Micronutrients for Health & Longevity | Dr. Rhonda Patrick
Huberman Lab Dr. Rhonda Patrick 2022-05-02

Dr. Rhonda Patrick discusses the critical role of micronutrients in health and longevity. She covers key vitamins and minerals, optimal intake levels, and how deficiencies accel...

4
The Advisor with Stacey Chillemi
Always Tired? Fix Hormone-Related Fatigue With These Supplements
The Advisor with Stacey Chillemi Carolyn Zollmeyer 2026-01-20

Nurse practitioner Carolyn Zollmeyer, who has treated over 25,000 patients with bioidentical hormone pellets, returns to discuss the supplement protocols she uses to optimize ho...

5
FoundMyFitness
#106 How To Increase Your Testosterone Levels Naturally | Derek from MPMD
FoundMyFitness Derek (More Plates More Dates) 2025-09-05

Fixing zinc, magnesium, and vitamin D deficiencies can boost testosterone by 100+ ng/dL. Covers proper testing protocols (timing matters), why free testosterone drops faster tha...

6
Mitolife Radio
The Dangers of Too Little Magnesium and Too Much Copper with Rick Malter
Mitolife Radio Rick Malter 2024-08-30

Rick Malter is a PhD and a veteran in the space of hair tissue mineral analysis (HTMA) testing. He was around when it was just getting started and in the early 2000s he decided ...

7
Mind Pump: Raw Fitness Truth
2650: Top 7 Underrated Supplements
Mind Pump: Raw Fitness Truth 2025-07-28

Sal DiStefano, Adam Schaefer, and Justin Andrews rank their top seven underrated supplements that most fitness enthusiasts overlook. The list covers vitamin D (cheap, widely def...

8
Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick
Huberman Lab Andrew Huberman 2026-01-01

Four micronutrients move the needle most for longevity: sulforaphane (from broccoli sprouts or moringa), omega-3s (target an Omega-3 Index above 8%), vitamin D (linked to all-ca...

9
The Dr. Layne Norton Podcast
Supplement Series: Tier 1
The Dr. Layne Norton Podcast 2026-03-02

Layne Norton kicks off his supplement series with his "Mount Rushmore" of ergogenic supplements: creatine monohydrate, whey protein, and caffeine. He walks through why these thr...

10
The Dr. Layne Norton Podcast
Supplement Series: Tier 2
The Dr. Layne Norton Podcast 2026-03-16

Layne Norton ranks his Tier 2 supplements -- the ones that show real promise but haven't earned Tier 1 status alongside creatine, whey, and caffeine. He walks through ashwagandh...

Related Research

The Effect of Creatine Supplementation on Resistance Training-Based Changes to Body Composition: A Systematic Review and Meta-analysis.
Desai I, Wewege MA, Jones MD, et al. (2025)
Creatine supplementation during resistance training increased lean body mass by 1.14 kg, reduced body fat percentage by 0.88%, and reduced fat mass by 0.73 kg compared to training alone.
Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials.
Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, et al. (2025)
Meta-analysis found collagen supplementation may improve knee osteoarthritis symptoms, though evidence quality varies and more rigorous trials are needed
Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review.
Rawji A, Peltier MR, Mourtzanakis K, et al. (2024)
Magnesium supplementation shows promising effects on reducing anxiety and improving sleep quality, though evidence is limited by heterogeneous study designs.
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.
Cruz-Sanabria F, Bruno S, Crippa A, et al. (2024)
Melatonin's sleep-promoting effects peak at 4 mg/day and are optimized when taken 3 hours before desired bedtime rather than the conventional 30 minutes before bed.
The effect of pre-exercise oral hyperhydration on endurance exercise performance, heart rate, and thermoregulation: a meta-analytical review.
McCubbin AJ, Irwin C (2024)
Pre-exercise hyperhydration (including sodium loading) provides small-to-moderate improvement in endurance performance, with a Hedges' g of 0.31 for time-to-exhaustion tasks.
The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.
Xu C, Bi S, Zhang W, et al. (2024)
Meta-analysis of 16 RCTs found creatine supplementation significantly improved memory (SMD = 0.31), attention time, and processing speed, with greater benefits in diseased populations and females.