Extreme Health Radio
Huberman Lab
Mitolife Radio
Ben Greenfield Life

Red Light Therapy

9 episodes B

Episodes covering red light therapy — protocols, research, and expert discussions.

Photobiomodulation using red (630-660nm) and near-infrared (810-850nm) light to enhance mitochondrial function, recovery, and brain health

Red light therapy (photobiomodulation) has moderate evidence across multiple domains - skin health, muscle recovery, cognitive function, and pain reduction. The mechanism is well-understood: red/NIR light is absorbed by cytochrome c oxidase in mitochondria, enhancing ATP production. Effect sizes are generally small to moderate, but it's low-risk and easy to implement.

Worth adding if you can afford a quality panel. Best evidence is for skin, recovery, and possibly cognitive function. Don't expect miracles, but the risk-benefit ratio is favorable.

Science & Mechanisms

Mechanisms:

  • Red/NIR light penetrates tissue and is absorbed by cytochrome c oxidase (Complex IV)
  • Enhances mitochondrial electron transport chain efficiency
  • Increases ATP production
  • Reduces oxidative stress and inflammation
  • May increase cerebral blood flow (brain applications)
  • Stimulates collagen production (skin applications)

Key studies:

Effect sizes:

  • Muscle recovery: Small to moderate effect
  • Skin health/collagen: Moderate effect
  • Cognitive function: Small effect (more research needed)
  • Pain reduction: Small to moderate effect

Limitations:

  • Many studies are small or industry-funded
  • Optimal dosing parameters still debated
  • Device quality varies enormously
  • Some claims are overhyped relative to evidence

Episodes

1
Extreme Health Radio
Matt Maruca – Principles of the Light Diet! Can You Live On Light?
Extreme Health Radio Matt Maruca 2026-01-24

Matt Maruca discusses the principles of the "Light Diet" - a framework centered on how light exposure affects human health and biology. Maruca, known for his work on circadian h...

2
Huberman Lab
Using Red Light to Improve Metabolism & the Harmful Effects of LEDs | Dr. Glen Jeffery
Huberman Lab Andrew Huberman 2025-12-01

Red and infrared light (670nm) penetrates tissue to boost mitochondrial function, improving blood glucose, slowing retinal aging, and potentially rescuing vision in macular dege...

3
Mitolife Radio
How to Safely Use Ultraviolet Light Therapy with Kris Sweeting
Mitolife Radio Kris Sweeting 2024-11-22

When we think of artificial ultraviolet light we often think of tanning beds. Most are unaware that tanning beds only contain one part of the ultraviolet spectrum, causing cellu...

4
Huberman Lab
AMA #14: 2023 Philanthropy, Evening Routine, Light Therapy, Health Metrics & More
Huberman Lab Andrew Huberman 2023-12-31

In this live-streamed premium AMA, Huberman begins by detailing the scientific research funded through Huberman Lab Premium in 2023, including gifts to laboratories studying min...

5
Huberman Lab
Using Light for Health
Huberman Lab Andrew Huberman 2022-04-18

Red and near-infrared light penetrate tissue to boost mitochondrial ATP production. Morning sunlight sets your circadian rhythm, while avoiding bright light at night protects sl...

6
Ben Greenfield Life
Light As Medicine, Metabolic Typing, COVID Controversies, Polar Bear Fitness, Healing Yourself With Laughter & More With Life Network Expert Dr. Leland Stillman
Ben Greenfield Life Leland Stillman 2026-01-17

Dr. Leland Stillman discusses how environmental factors shape health regardless of diet or exercise. Topics include sunlight as medicine, circadian lighting, EMF exposure, breat...

7
Ben Greenfield Life
The SUPERHUMAN Protocol That Declumps Cells, Hyperoxygenates The Body, Restores Cellular Wellness & *Much* More, With Gary Brecka (Best of LIFE Network's Experts!)
Ben Greenfield Life Gary Brecka 2025-10-11

Ben Greenfield features Gary Brecka, a leading expert in human biology and longevity, in this Best of LIFE Network episode. Brecka, the former Chief Human Biologist and co-found...

8
Mitolife Radio
Circadian Health Tips with Sarah Kleiner
Mitolife Radio Sarah Kleiner 2024-12-06

What happens to our health if the body thinks that its daytime when its nighttime and nighttime when its daytime? Sarah Kleiner shares her experience healing herself of Hashimot...

9
The Home Laser That Reverses Skin Age By 20 Years
The Human Upgrade: Biohacking for Longevity & Performance 2026-02-24

Dave Asprey interviews Lucy Gough, founder of LYMA Lasers, about a new class of at-home laser devices that go beyond LED to regenerate skin, muscle, and even cartilage without t...

Related Research

Effects of photobiomodulation on multiple health outcomes: an umbrella review of randomized clinical trials.
Son Y, Lee H, Yu S, et al. (2025)
Umbrella review of 20 systematic reviews found photobiomodulation has significant benefits for pain reduction, functional recovery, wound healing, and inflammation, though evidence quality varies across outcomes.
Photobiomodulation in the aging brain: a systematic review from animal models to humans.
Rodríguez-Fernández L, Zorzo C, Arias JL (2024)
Photobiomodulation demonstrates neuroprotective, anti-inflammatory, and mitochondrial-restoring effects in the aging brain, improving working memory, cognitive inhibition, and general cognition in both animal models and humans
Photobiomodulation therapy (red/NIR LEDs) reduced the length of stay in intensive care unit and improved muscle function: A randomized, triple-blind, and sham-controlled trial.
Neto RPM, Espósito LMB, da Rocha FC, et al. (2024)
Triple-blind sham-controlled RCT found that photobiomodulation with red/NIR LEDs reduced ICU length of stay and improved muscle function in critically ill patients.
Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial.
Mota LR, Duarte IdS, Galache TR, et al. (2023)
RCT demonstrated that photobiomodulation reduced periocular wrinkle volume by 30% compared to baseline, supporting red light therapy's efficacy for skin anti-aging.
Can transcranial photobiomodulation improve cognitive function? A systematic review of human studies.
Lee T, Ding Z, Chan AS (2022)
29 of 35 human studies (83%) found that transcranial photobiomodulation improved cognitive function, with strongest evidence in dementia and mild cognitive impairment
Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations
Zomorrodi R, Loheswaran G, Pushparaj A, Bhardwaj R, Bhimani R (2020)
Intranasal and transcranial photobiomodulation modulates brain oscillations associated with cognitive function